U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 694725, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
RAF1provided by VGNC
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:76649
See related
Ensembl:ENSMMUG00000007450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RAF1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (143956554..144039447, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (53732851..53818349)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene transmembrane protein 40 Neighboring gene keratin, type I cytoskeletal 18 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
v-raf-1 murine leukemia viral oncogene homolog 1
NP_001253231.1
XP_014985690.1
XP_014985692.1
XP_028698921.1
XP_028698922.1
XP_028698923.1
XP_028698924.1
XP_028698925.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266302.1 → NP_001253231.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001253231.1

    Status: PROVISIONAL

    Source sequence(s)
    JV047817
    UniProtKB/TrEMBL
    F6SWC0, G7MKP4
    Related
    ENSMMUP00000009777.2, ENSMMUT00000010416.4
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    143956554..144039447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028843088.1 → XP_028698921.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9U8, G7MKP4
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

  2. XM_028843092.1 → XP_028698925.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    G7MKP4
    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:58 → 103
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_015130206.2 → XP_014985692.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    G7MKP4
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:58 → 106
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_015130204.2 → XP_014985690.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    F6SWC0, G7MKP4
    Related
    ENSMMUP00000067200.1, ENSMMUT00000088856.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_028843090.1 → XP_028698923.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9U8, G7MKP4
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

  6. XM_028843091.1 → XP_028698924.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9U8, G7MKP4
    Related
    ENSMMUP00000057089.1, ENSMMUT00000072482.2
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

  7. XM_028843089.1 → XP_028698922.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9U8, G7MKP4
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.