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ACKR3 atypical chemokine receptor 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 694428, updated on 17-Aug-2024

Summary

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Official Symbol
ACKR3provided by VGNC
Official Full Name
atypical chemokine receptor 3provided by VGNC
Primary source
VGNC:VGNC:69513
Locus tag
EGK_04929
See related
Ensembl:ENSMMUG00000060487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
CXCR7
Orthologs
human mouse all
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Genomic context

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See ACKR3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
5
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (123965949..123980445)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (119253681..119268153)

Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene 60S ribosomal protein L3 pseudogene Neighboring gene uncharacterized LOC114671450 Neighboring gene uncharacterized LOC114671451 Neighboring gene uncharacterized LOC114671452

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells. Jin J, et al. Ophthalmic Res, 2013. PMID 23549077
  2. TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression. Feng YF, et al. Mol Cell Biochem, 2014 Dec. PMID 25138701
  3. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1-induced RF/6A cell migration and tube formation.
    Title: TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression.
  2. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
    Title: CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
atypical chemokine receptor 3
Names
C-X-C chemokine receptor type 7
chemokine (C-X-C motif) receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261729.1 → NP_001248658.1  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_001248658.1

    Status: PROVISIONAL

    Source sequence(s)
    JV043892
    UniProtKB/TrEMBL
    A0A8J8YNH9, F7GTL4, G7N989
    Related
    ENSMMUP00000076930.1, ENSMMUT00000107472.1
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041765.1 Reference Mmul_10 Primary Assembly

    Range
    123965949..123980445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015111240.2 → XP_014966726.1  atypical chemokine receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8J8YNH9, F7GTL4, G7N989
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_015111241.2 → XP_014966727.1  atypical chemokine receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8J8YNH9, F7GTL4, G7N989
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_028830379.1 → XP_028686212.1  atypical chemokine receptor 3 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZVH9
    Related
    ENSMMUP00000068645.1, ENSMMUT00000083317.1
    Conserved Domains (1) summary
    cd14987
    Location:68 → 349
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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