Dennd6b DENN domain containing 6B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dennd6bprovided by MGI
Official Full Name: DENN domain containing 6Bprovided by MGI
Primary source: MGI:MGI:1916690
See related: Ensembl:ENSMUSG00000015377 AllianceGenome:MGI:1916690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam116b; 1700027J05Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 33.8), cerebellum adult (RPKM 32.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.7 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89066416..89080793, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89182213..89198427, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

AI414881 (e-PCR)
- UniSTS:180815

BB195788 (e-PCR)
- UniSTS:209128

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein DENND6B

Names: DENN domain-containing protein 6B; DENN/MADD domain containing 6B; family with sequence similarity 116, member B; protein FAM116B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027081.3 → NP_081357.2 protein DENND6B

See identical proteins and their annotated locations for NP_081357.2

Status: VALIDATED

Source sequence(s)

AK006427, BB658928, BC058958, BQ444357, BY252285

Consensus CDS

CCDS57000.1

UniProtKB/Swiss-Prot

B2RSU3, Q9D9V7

Related

ENSMUSP00000077978.8, ENSMUST00000078953.9

Conserved Domains (2) summary

pfam08616
Location:250 → 356

SPA; Stabilization of polarity axis

cl11519
Location:151 → 311

DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

89066416..89080793 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248748.1 → XP_030104608.1 protein DENND6B isoform X3

Conserved Domains (2) summary

pfam08616
Location:126 → 232

SPA; Stabilization of polarity axis

cl11519
Location:28 → 187

DENN; DENN (AEX-3) domain
XM_030248747.2 → XP_030104607.1 protein DENND6B isoform X2

Conserved Domains (2) summary

pfam08616
Location:153 → 259

SPA; Stabilization of polarity axis

cl11519
Location:54 → 214

DENN; DENN (AEX-3) domain
XM_030248744.2 → XP_030104604.1 protein DENND6B isoform X1

Conserved Domains (2) summary

pfam08616
Location:223 → 329

SPA; Stabilization of polarity axis

cl11519
Location:125 → 284

DENN; DENN (AEX-3) domain