DRD2 dopamine receptor D2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: DRD2provided by VGNC
Official Full Name: dopamine receptor D2provided by VGNC
Primary source: VGNC:VGNC:71989
See related: Ensembl:ENSMMUG00000014334
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	14	NC_041767.1 (106549673..106616381, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	14	NC_027906.1 (106270721..106337408, complement)

Chromosome 14 - NC_041767.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons.
Title: Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons.
Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.
Title: Dopamine Receptors Influence Internally Generated Oscillations during Rule Processing in Primate Prefrontal Cortex.
findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.
Title: Dopamine receptors differentially enhance rule coding in primate prefrontal cortex neurons.
Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.
Title: Extrastriatal D2-like receptors modulate basal ganglia pathways in normal and Parkinsonian monkeys.
Mapped associations occur between changes in D2 and D3 dopamine receptor occupancy and brain hemodynamics
Title: Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI.
These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.
Title: PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys.

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General gene information

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Markers

SGC31507 (e-PCR)
- UniSTS:56642

MARC_13871-13872:1007494510:1 (e-PCR)
- UniSTS:267588

DRD2 (e-PCR), detects polymorphism
- UniSTS:262987

GDB:196340 (e-PCR)
- UniSTS:155832

PMC311033P6 (e-PCR)
- UniSTS:272844

Drd2 (e-PCR), detects polymorphism
- UniSTS:506860

DRD2 (e-PCR), detects polymorphism
- UniSTS:266487

GDB:182528 (e-PCR)
- UniSTS:155387

G10651 (e-PCR)
- UniSTS:60667

SHGC-148803 (e-PCR)
- UniSTS:173055

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: D(2) dopamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041767.1 Reference Mmul_10 Primary Assembly

Range

106549673..106616381 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001085571.4 → XP_001085571.1 D(2) dopamine receptor

See identical proteins and their annotated locations for XP_001085571.1

UniProtKB/TrEMBL

F7CYH8, G7NC25

Related

ENSMMUP00000018834.2, ENSMMUT00000020122.4

Conserved Domains (1) summary

cd15309
Location:35 → 437

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors