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AZIN1 antizyme inhibitor 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 693581, updated on 17-Aug-2024

Summary

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Official Symbol
AZIN1provided by VGNC
Official Full Name
antizyme inhibitor 1provided by VGNC
Primary source
VGNC:VGNC:70080
See related
Ensembl:ENSMMUG00000001338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Dec 2014]
Orthologs
human mouse all
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Genomic context

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See AZIN1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
13
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (103100385..103139232, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (101555085..101593808, complement)

Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106999894 Neighboring gene uncharacterized LOC114680430 Neighboring gene uncharacterized LOC106999895 Neighboring gene nucleophosmin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Kahana C. Essays Biochem, 2009 Nov 4. PMID 20095969
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ornithine decarboxylase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ornithine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in putrescine biosynthetic process from ornithine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
antizyme inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260734.1 → NP_001247663.1  antizyme inhibitor 1

    See identical proteins and their annotated locations for NP_001247663.1

    Status: REVIEWED

    Source sequence(s)
    JV043928
    UniProtKB/TrEMBL
    F7B9N8, G7MZW6
    Related
    ENSMMUP00000001788.2, ENSMMUT00000001894.4
    Conserved Domains (1) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041761.1 Reference Mmul_10 Primary Assembly

    Range
    103100385..103139232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028852109.1 → XP_028707942.1  antizyme inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    G7MZW6
    Conserved Domains (1) summary
    cd06831
    Location:26 → 418
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  2. XM_028852112.1 → XP_028707945.1  antizyme inhibitor 1 isoform X3

    Conserved Domains (1) summary
    cl00261
    Location:1 → 252
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes

  3. XM_028852110.1 → XP_028707943.1  antizyme inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    G7MZW6
    Conserved Domains (1) summary
    cd06831
    Location:26 → 418
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  4. XM_028852113.1 → XP_028707946.1  antizyme inhibitor 1 isoform X3

    Conserved Domains (1) summary
    cl00261
    Location:1 → 252
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes

  5. XM_028852111.1 → XP_028707944.1  antizyme inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    G7MZW6
    Conserved Domains (1) summary
    cd06831
    Location:26 → 418
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  6. XM_028852106.1 → XP_028707939.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    F7B9N8, G7MZW6
    Related
    ENSMMUP00000074038.1, ENSMMUT00000106878.1
    Conserved Domains (1) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  7. XM_028852107.1 → XP_028707940.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    F7B9N8, G7MZW6
    Conserved Domains (1) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  8. XM_028852108.1 → XP_028707941.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    F7B9N8, G7MZW6
    Conserved Domains (1) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
Nucleotide Protein
Heading Accession and Version

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