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IBTK inhibitor of Bruton tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 693559, updated on 17-Aug-2024

Summary

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Official Symbol
IBTKprovided by VGNC
Official Full Name
inhibitor of Bruton tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:73409
See related
Ensembl:ENSMMUG00000010749
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See IBTK in Genome Data Viewer
Location:
chromosome: 4
Exon count:
29
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (90845639..90925226)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (80363687..80443320, complement)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene trophoblast glycoprotein Neighboring gene single-stranded DNA-binding protein 2 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106998000 Neighboring gene uncharacterized LOC106997999

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of Bruton tyrosine kinase
Names
inhibitor of Bruton agammaglobulinemia tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    90845639..90925226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015136836.2 → XP_014992322.1  inhibitor of Bruton tyrosine kinase isoform X2

    UniProtKB/TrEMBL
    H9Z7G8
    Conserved Domains (8) summary
    smart00225
    Location:768 → 864
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:240 → 457
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:25 → 135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:836 → 896
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:195 → 244
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:553 → 641
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 116
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 82
    ANK; ANK repeat [structural motif]

  2. XM_015136835.2 → XP_014992321.1  inhibitor of Bruton tyrosine kinase isoform X1

    UniProtKB/TrEMBL
    F7FYD2, H9FSP2, H9Z7G8
    Related
    ENSMMUP00000014079.3, ENSMMUT00000015027.4
    Conserved Domains (8) summary
    smart00225
    Location:768 → 866
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:240 → 457
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:25 → 135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:870 → 930
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:195 → 244
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:760 → 866
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 116
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 82
    ANK; ANK repeat [structural motif]
Nucleotide Protein
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