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Lrrc46 leucine rich repeat containing 46 [ Mus musculus (house mouse) ]

Gene ID: 69297, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrc46provided by MGI
Official Full Name
leucine rich repeat containing 46provided by MGI
Primary source
MGI:MGI:1916547
See related
Ensembl:ENSMUSG00000020878 AllianceGenome:MGI:1916547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700006D24Rik
Summary
Is expressed in 4th ventricle lateral recess; lateral ventricle choroid plexus; and olfactory epithelium. Orthologous to human LRRC46 (leucine rich repeat containing 46). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 330.8) See more
Orthologs
human all
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Genomic context

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See Lrrc46 in Genome Data Viewer
Location:
11 D; 11 60.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96925428..96932195, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97034602..97041369, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene trans-acting transcription factor 6 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene predicted gene 11532 Neighboring gene secernin 2 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene STARR-positive B cell enhancer ABC_E8445 Neighboring gene oxysterol binding protein-like 7 Neighboring gene predicted gene, 51917

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of LRRC46 as a novel candidate gene for high myopia. Jiang L, et al. Sci China Life Sci, 2024 Sep. PMID 38874710
  2. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. Yin Y, et al. Int J Mol Sci, 2022 Jul 31. PMID 35955660, Free PMC Article
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of LRRC46 as a novel candidate gene for high myopia.
    Title: Identification of LRRC46 as a novel candidate gene for high myopia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027026.2 → NP_081302.2  leucine-rich repeat-containing protein 46

    See identical proteins and their annotated locations for NP_081302.2

    Status: PROVISIONAL

    Source sequence(s)
    BC022723
    Consensus CDS
    CCDS25311.1
    UniProtKB/Swiss-Prot
    Q8R1Z3, Q9DAP0
    Related
    ENSMUSP00000021251.7, ENSMUST00000021251.7
    Conserved Domains (2) summary
    sd00031
    Location:50 → 71
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:60 → 146
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96925428..96932195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAP0.2 GenPept UniProtKB/Swiss-Prot:Q9DAP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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