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Rfc3 replication factor C (activator 1) 3 [ Mus musculus (house mouse) ]

Gene ID: 69263, updated on 27-Nov-2024

Summary

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Official Symbol
Rfc3provided by MGI
Official Full Name
replication factor C (activator 1) 3provided by MGI
Primary source
MGI:MGI:1916513
See related
Ensembl:ENSMUSG00000033970 AllianceGenome:MGI:1916513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
38kDa; Recc3; 2810416I22Rik
Summary
Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to DNA binding activity; DNA clamp loader activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in central nervous system; liver; retina nuclear layer; skeletal muscle; and submandibular gland primordium. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 28.7), liver E14 (RPKM 20.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rfc3 in Genome Data Viewer
Location:
5 G3; 5 90.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (151566282..151574673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (151642817..151651208, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 27 Neighboring gene vomeronasal 2, receptor, pseudogene 28 Neighboring gene STARR-positive B cell enhancer ABC_E1699 Neighboring gene predicted gene, 24242 Neighboring gene STARR-seq mESC enhancer starr_14978 Neighboring gene STARR-seq mESC enhancer starr_14979 Neighboring gene STARR-seq mESC enhancer starr_14980 Neighboring gene STARR-positive B cell enhancer mm9_chr5:152537120-152537217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells. Gonzalez J, et al. Blood, 2003 Apr 1. PMID 12406903
  2. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Gray S, et al. Cell Rep, 2020 Jul 7. PMID 32640224, Free PMC Article
  3. cDNAs encoding the large subunit of human replication factor C. Bunz F, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248204, Free PMC Article
  4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
  5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells.
    Title: A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to organophosphorus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 3
Names
A1 38 kDa subunit
RF-C 38 kDa subunit
RFC38
activator 1 38 kDa subunit
activator 1 subunit 3
replication factor C 3
replication factor C 38 kDa subunit
replication factor C, 38 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417694.1 → NP_001404623.1  replication factor C subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120011

  2. NM_001417695.1 → NP_001404624.1  replication factor C subunit 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120011

  3. NM_027009.3 → NP_081285.1  replication factor C subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_081285.1

    Status: VALIDATED

    Source sequence(s)
    AC120011
    Consensus CDS
    CCDS39413.1
    UniProtKB/Swiss-Prot
    Q8R323
    UniProtKB/TrEMBL
    Q3TKD1
    Related
    ENSMUSP00000039621.10, ENSMUST00000038131.10
    Conserved Domains (1) summary
    PRK12402
    Location:3 → 339
    PRK12402; replication factor C small subunit 2; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    151566282..151574673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254788.1 → XP_030110648.1  replication factor C subunit 3 isoform X1

    Conserved Domains (1) summary
    PRK12402
    Location:76 → 287
    PRK12402; replication factor C small subunit 2; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R323.1 GenPept UniProtKB/Swiss-Prot:Q8R323

Gene LinkOut

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