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Gp1ba glycoprotein Ib platelet subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 691992, updated on 9-Dec-2024

Summary

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Official Symbol
Gp1baprovided by RGD
Official Full Name
glycoprotein Ib platelet subunit alphaprovided by RGD
Primary source
RGD:1310239
See related
EnsemblRapid:ENSRNOG00000025959 AllianceGenome:RGD:1310239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and plasma membrane. Predicted to be part of glycoprotein Ib-IX-V complex. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome; Bernard-Soulier syndrome type A2; myocardial infarction; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 3. Orthologous to human GP1BA (glycoprotein Ib platelet subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 40.6), Muscle (RPKM 15.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gp1ba in Genome Data Viewer
Location:
10q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55831901..55856729)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55352938..55355804)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57260680..57263546)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480817 Neighboring gene misshapen-like kinase 1 Neighboring gene similar to human chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene solute carrier family 25 member 11 Neighboring gene ring finger protein 167 Neighboring gene profilin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Nieswandt B, et al. Blood, 2000 Oct 1. PMID 11001906
  2. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Webster ML, et al. Blood, 2006 Aug 1. PMID 16861348
  3. Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease. Othman M, et al. Blood, 2005 Jun 1. PMID 15705799
  4. Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms. Morisaki H, et al. Anesthesiology, 2002 Sep. PMID 12218538
  5. Surface markers of platelet function in idiopathic nephrotic syndrome in children. Tkaczyk M, et al. Pediatr Nephrol, 2002 Aug. PMID 12185480

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation, intrinsic pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in fibrinolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycoprotein Ib-IX-V complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
platelet glycoprotein Ib alpha chain
Names
glycoprotein 1b, alpha polypeptide
glycoprotein Ib (platelet), alpha polypeptide
glycoprotein Ib platelet alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109654.1 → NP_001103124.1  platelet glycoprotein Ib alpha chain precursor

    See identical proteins and their annotated locations for NP_001103124.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HG72, D3ZQU7
    Conserved Domains (7) summary
    smart00013
    Location:20 → 49
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:50 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:51 → 72
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:164 → 204
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:94 → 152
    LRR_8; Leucine rich repeat
    pfam16031
    Location:404 → 523
    TonB_N; TonB N-terminal region
    cl15307
    Location:221 → 281
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55831901..55856729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269910.1 → XP_063125980.1  platelet glycoprotein Ib alpha chain isoform X1

    UniProtKB/TrEMBL
    A6HG72, D3ZQU7
    Related
    ENSRNOP00000105269.1, ENSRNOT00000159517.1
Nucleotide Protein Strain
Heading Accession and Version

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