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Dhx16 DEAH-box helicase 16 [ Mus musculus (house mouse) ]

Gene ID: 69192, updated on 27-Nov-2024

Summary

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Official Symbol
Dhx16provided by MGI
Official Full Name
DEAH-box helicase 16provided by MGI
Primary source
MGI:MGI:1916442
See related
Ensembl:ENSMUSG00000024422 AllianceGenome:MGI:1916442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBP2; Ddx16; mKIAA0577; 2410006N22Rik
Summary
Predicted to enable several functions, including helicase activity; pattern recognition receptor activity; and ubiquitin binding activity. Predicted to be involved in antiviral innate immune response and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 30.7), testis adult (RPKM 23.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx16 in Genome Data Viewer
Location:
17 B1; 17 18.74 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36190657..36203562)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35879764..35892670)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene nurim (nuclear envelope membrane protein) Neighboring gene STARR-seq mESC enhancer starr_42480 Neighboring gene protein phosphatase 1, regulatory subunit 18 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36016615-36016802 Neighboring gene RIKEN cDNA 2310061I04 gene Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bovine mannosidosis--a model lysosomal storage disease. Jolly RD, et al. Birth Defects Orig Artic Ser, 1975. PMID 100
  2. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Hage A, et al. Cell Rep, 2022 Mar 8. PMID 35263596, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
NP_081263.2
XP_006524936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026987.2 → NP_081263.2  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

    See identical proteins and their annotated locations for NP_081263.2

    Status: VALIDATED

    Source sequence(s)
    AI853344, AK010431, BC138205, BU054791, CJ141265
    Consensus CDS
    CCDS28710.1
    UniProtKB/TrEMBL
    G3X8X0, Q921Y1
    Related
    ENSMUSP00000025292.9, ENSMUST00000025292.15
    Conserved Domains (2) summary
    PTZ00121
    Location:147 → 410
    PTZ00121; MAEBL; Provisional
    COG1643
    Location:377 → 1031
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36190657..36203562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524873.1 → XP_006524936.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    UniProtKB/TrEMBL
    Q921Y1
    Conserved Domains (2) summary
    PTZ00121
    Location:147 → 410
    PTZ00121; MAEBL; Provisional
    COG1643
    Location:377 → 1036
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003952176.2 RNA Sequence

  2. XR_876528.4 RNA Sequence

    Related
    ENSMUST00000174366.8

  3. XR_001782109.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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