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Pdia2 protein disulfide isomerase associated 2 [ Mus musculus (house mouse) ]

Gene ID: 69191, updated on 4-Jan-2025

Summary

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Official Symbol
Pdia2provided by MGI
Official Full Name
protein disulfide isomerase associated 2provided by MGI
Primary source
MGI:MGI:1916441
See related
Ensembl:ENSMUSG00000024184 AllianceGenome:MGI:1916441
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdip; Pdipl; 1810041F13Rik
Summary
Predicted to enable protein-disulfide reductase activity. Acts upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in lens; lens epithelium; lens fiber; lens vesicle; and lens vesicle epithelium. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in stomach adult (RPKM 77.1), small intestine adult (RPKM 48.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Pdia2 in Genome Data Viewer
Location:
17 A3.3; 17 13.07 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26414973..26418108, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26195999..26199134, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5580 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E7501 Neighboring gene axin 1 Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene regulator of G-protein signaling 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a pancreas-specific protein disulfide isomerase, PDIp. Desilva MG, et al. DNA Cell Biol, 1997 Mar. PMID 9115635
  2. Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait. Lan H, et al. Diabetes, 2004 Jan. PMID 14693722
  3. Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions. Fu XM, et al. J Mol Histol, 2009 Jun. PMID 19821078
  4. Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase. Toldo S, et al. Mol Med, 2011 Sep-Oct. PMID 21637911, Free PMC Article
  5. [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system]. Calderón MN, et al. Biomedica, 2011 Mar. PMID 22159485

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rotavirus-protein disulfide isomerase interaction was demonstrated in vitro as well as inMA104 cells and intestinal villi from suckling mice.
    Title: [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system].
  2. Data show that diabetic mice had a worse postinfarction remodeling associated with an altered protein disulfide isomerase (PDI). redox state.
    Title: Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase.
  3. The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer.
    Title: Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.
  4. Elevated Pdi expression is cis regulated and is not linked to diabetes susceptibility.
    Title: Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144891

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A2
Names
protein disulfide isomerase (pancreas) like
protein disulfide isomerase, pancreatic
NP_001074539.1
XP_006524935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081070.1 → NP_001074539.1  protein disulfide-isomerase A2 precursor

    See identical proteins and their annotated locations for NP_001074539.1

    Status: PROVISIONAL

    Source sequence(s)
    AC126438
    Consensus CDS
    CCDS37510.1
    UniProtKB/Swiss-Prot
    D3Z6P0, Q14AV9
    Related
    ENSMUSP00000035584.8, ENSMUST00000039113.14
    Conserved Domains (5) summary
    cd02961
    Location:48 → 150
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    cd02981
    Location:158 → 257
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:262 → 371
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:392 → 494
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01130
    Location:45 → 506
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26414973..26418108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524872.2 → XP_006524935.1  protein disulfide-isomerase A2 isoform X1

    Conserved Domains (1) summary
    TIGR01130
    Location:45 → 467
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z6P0.1 GenPept UniProtKB/Swiss-Prot:D3Z6P0

Gene LinkOut

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