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C1qtnf2 C1q and tumor necrosis factor related protein 2 [ Mus musculus (house mouse) ]

Gene ID: 69183, updated on 27-Nov-2024

Summary

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Official Symbol
C1qtnf2provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 2provided by MGI
Primary source
MGI:MGI:1916433
See related
Ensembl:ENSMUSG00000046491 AllianceGenome:MGI:1916433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adih; CTRP2; 1810033K05Rik
Summary
Enables identical protein binding activity and signaling receptor binding activity. Involved in regulation of lipid metabolic process. Acts upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skeleton. Orthologous to human C1QTNF2 (C1q and TNF related 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 20.0), bladder adult (RPKM 18.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See C1qtnf2 in Genome Data Viewer
Location:
11 25.72 cM; 11 B1.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43364984..43382485)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43474306..43491525)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151 Neighboring gene STARR-seq mESC enhancer starr_29256 Neighboring gene cyclin J-like Neighboring gene STARR-seq mESC enhancer starr_29259 Neighboring gene STARR-seq mESC enhancer starr_29260 Neighboring gene fatty acid binding protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion. Ye M, et al. Diab Vasc Dis Res, 2022 Nov-Dec. PMID 36409464, Free PMC Article
  2. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. Peterson JM, et al. PLoS One, 2014. PMID 24586339, Free PMC Article
  3. C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion. Lei X, et al. J Biol Chem, 2019 Oct 25. PMID 31439668, Free PMC Article
  4. Expression of adipokines in preimplantation rabbit and mice embryos. Schmidt T, et al. Histochem Cell Biol, 2008 Jun. PMID 18330590
  5. A family of Acrp30/adiponectin structural and functional paralogs. Wong GW, et al. Proc Natl Acad Sci U S A, 2004 Jul 13. PMID 15231994, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemiareperfusion.
    Title: C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion.
  2. CTRP2 regulates lipid metabolism in adipose tissue and liver.
    Title: C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion.
  3. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.
    Title: CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of D-glucose import IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fatty acid oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 2
Names
adiponectin h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026979.6 → NP_081255.2  complement C1q tumor necrosis factor-related protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670472
    Consensus CDS
    CCDS24558.1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    43364984..43382485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156958.1 → XP_036012851.1  complement C1q tumor necrosis factor-related protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D8U4
    UniProtKB/TrEMBL
    A0A3B0IYV7
    Related
    ENSMUSP00000051652.4, ENSMUST00000057679.10
    Conserved Domains (2) summary
    pfam00386
    Location:160 → 284
    C1q; C1q domain
    pfam01391
    Location:79 → 130
    Collagen; Collagen triple helix repeat (20 copies)

  2. XM_036156959.1 → XP_036012852.1  complement C1q tumor necrosis factor-related protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D8U4
    UniProtKB/TrEMBL
    A0A3B0IYV7
    Conserved Domains (2) summary
    pfam00386
    Location:160 → 284
    C1q; C1q domain
    pfam01391
    Location:79 → 130
    Collagen; Collagen triple helix repeat (20 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U4.1 GenPept UniProtKB/Swiss-Prot:Q9D8U4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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