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Tpmt thiopurine S-methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 690050, updated on 4-Jan-2025

Summary

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Official Symbol
Tpmtprovided by RGD
Official Full Name
thiopurine S-methyltransferaseprovided by RGD
Primary source
RGD:1585162
See related
EnsemblRapid:ENSRNOG00000016468 AllianceGenome:RGD:1585162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and poor metabolism of thiopurines 1. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 393.7), Liver (RPKM 196.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpmt in Genome Data Viewer
Location:
17p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17850308..17868976)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17644088..17662709)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18029090..18047716)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene DEK proto-oncogene Neighboring gene lysine demethylase 1B Neighboring gene NLR family, pyrin domain containing 4E like, pseudogene 1 Neighboring gene NHL repeat containing E3 ubiquitin protein ligase 1 Neighboring gene NFKB inhibitor interacting Ras-like 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients. Ayesh BM, et al. BMC Hematol, 2013 Apr 10. PMID 24499706, Free PMC Article
  2. Thiopurine methyltransferase regulation in rat kidney: immunoprecipitation studies. Hernández JS, et al. Xenobiotica, 1991 Apr. PMID 1897245
  3. Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver. Loo G, et al. Biochem Biophys Res Commun, 1985 Apr 30. PMID 3994729
  4. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Gisbert JP, et al. Am J Gastroenterol, 2006 Dec. PMID 17026564
  5. Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. Chen D, et al. Clin Rheumatol, 2014 Apr. PMID 24322830

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols.
    Title: Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables thiopurine S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiopurine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiopurine S-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thiopurine S-methyltransferase
Names
thiopurine methyltransferase
NP_001382599.1
XP_038952015.1
XP_038952016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395670.1 → NP_001382599.1  thiopurine S-methyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q9Z0T0
    UniProtKB/TrEMBL
    A0A0G2K2B6, B0BMT6
    Related
    ENSRNOP00000022084.7, ENSRNOT00000022085.8
    Conserved Domains (1) summary
    pfam05724
    Location:19 → 240
    TPMT; Thiopurine S-methyltransferase (TPMT)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    17850308..17868976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096087.2 → XP_038952015.1  thiopurine S-methyltransferase isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:19 → 135
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_039096088.2 → XP_038952016.1  thiopurine S-methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:19 → 135
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001079531.1: Suppressed sequence

    Description
    NM_001079531.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0T0.1 GenPept UniProtKB/Swiss-Prot:Q9Z0T0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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