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Mtmr11 myotubularin related protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689613, updated on 4-Jan-2025

Summary

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Official Symbol
Mtmr11provided by RGD
Official Full Name
myotubularin related protein 11provided by RGD
Primary source
RGD:1589965
See related
EnsemblRapid:ENSRNOG00000021176 AllianceGenome:RGD:1589965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR11 (myotubularin related protein 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 151.3), Kidney (RPKM 111.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtmr11 in Genome Data Viewer
Location:
2q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186410851..186421024)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183721983..183732148)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198301666..198311787)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485652 Neighboring gene uncharacterized LOC134485654 Neighboring gene OTU deubiquitinase 7B Neighboring gene developmental pluripotency-associated 4, pseudogene 7 Neighboring gene splicing factor 3B subunit 4 Neighboring gene synaptic vesicle glycoprotein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
  2. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myotubularin-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191096.1 → NP_001178025.1  myotubularin-related protein 11

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D3ZQH5
    Related
    ENSRNOP00000053101.3, ENSRNOT00000056262.4
    Conserved Domains (3) summary
    pfam12578
    Location:553 → 683
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:51 → 165
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:195 → 469
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186410851..186421024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761329.4 → XP_008759551.1  myotubularin-related protein 11 isoform X2

    UniProtKB/TrEMBL
    D3ZQH5
    Conserved Domains (3) summary
    pfam12578
    Location:542 → 672
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:40 → 154
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:184 → 458
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_063282578.1 → XP_063138648.1  myotubularin-related protein 11 isoform X1

    UniProtKB/TrEMBL
    D3ZQH5

  3. XM_063282579.1 → XP_063138649.1  myotubularin-related protein 11 isoform X3

    UniProtKB/TrEMBL
    D3ZQH5

  4. XM_063282580.1 → XP_063138650.1  myotubularin-related protein 11 isoform X4

    UniProtKB/TrEMBL
    D3ZQH5
    Related
    ENSRNOP00000099302.1, ENSRNOT00000157745.1

  5. XM_063282581.1 → XP_063138651.1  myotubularin-related protein 11 isoform X5

  6. XM_063282583.1 → XP_063138653.1  myotubularin-related protein 11 isoform X7

  7. XM_063282584.1 → XP_063138654.1  myotubularin-related protein 11 isoform X8

  8. XM_063282582.1 → XP_063138652.1  myotubularin-related protein 11 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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