U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbc1d22a TBC1 domain family, member 22a [ Rattus norvegicus (Norway rat) ]

Gene ID: 689443, updated on 27-Dec-2024

Summary

Go to the top of the page Help
Symbol
Tbc1d22aprovided by RGD
Full Name
TBC1 domain family, member 22aprovided by RGD
Primary source
RGD:1306588
See related
EnsemblRapid:ENSRNOG00000017057 AllianceGenome:RGD:1306588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306588
Summary
Predicted to enable 14-3-3 protein binding activity; GTPase activator activity; and protein homodimerization activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 49.9), Thymus (RPKM 49.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tbc1d22a in Genome Data Viewer
Location:
7q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (119172284..119457271)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (117292481..117577473)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (127081769..127227601)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 4 Neighboring gene uncharacterized LOC134479762 Neighboring gene ceramide kinase Neighboring gene TBC1 domain family, member 22a like Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134479764 Neighboring gene uncharacterized LOC134479763 Neighboring gene uncharacterized LOC134479765

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. Tempel W, et al. Proteins, 2008 Apr. PMID 18186464
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. Greninger AL, et al. mBio, 2013 Apr 9. PMID 23572552, Free PMC Article
  3. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TBC1 domain family member 22A
Names
TBC1 domain family member 22A-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401878.2 → NP_001388807.1  TBC1 domain family member 22A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AH78
    Related
    ENSRNOP00000101010.1, ENSRNOT00000152968.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    119172284..119457271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080323.2 → XP_038936251.1  TBC1 domain family member 22A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPV1, A0A8I6AH78
    Related
    ENSRNOP00000080048.1, ENSRNOT00000094564.2
    Conserved Domains (1) summary
    pfam00566
    Location:276 → 466
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. XM_039080326.2 → XP_038936254.1  TBC1 domain family member 22A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AH78
    Conserved Domains (1) summary
    smart00164
    Location:216 → 442
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. XM_039080327.2 → XP_038936255.1  TBC1 domain family member 22A isoform X3

    Conserved Domains (1) summary
    pfam00566
    Location:50 → 240
    RabGAP-TBC; Rab-GTPase-TBC domain

RNA

  1. XR_005487292.2 RNA Sequence

  2. XR_593675.4 RNA Sequence

    Related
    ENSRNOT00000022945.9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials