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Adgrd1 adhesion G protein-coupled receptor D1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689257, updated on 27-Nov-2024

Summary

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Official Symbol
Adgrd1provided by RGD
Official Full Name
adhesion G protein-coupled receptor D1provided by RGD
Primary source
RGD:1594795
See related
EnsemblRapid:ENSRNOG00000023536 AllianceGenome:RGD:1594795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr133
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nuclear speck. Predicted to be active in plasma membrane. Orthologous to human ADGRD1 (adhesion G protein-coupled receptor D1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 27.6), Muscle (RPKM 16.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adgrd1 in Genome Data Viewer
Location:
12q13
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33124981..33239778, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27488908..27603714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31134806..31249594, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555340 Neighboring gene uncharacterized LOC134481332 Neighboring gene uncharacterized LOC134481179 Neighboring gene uncharacterized LOC120095936 Neighboring gene uncharacterized LOC120095937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell adhesion receptor GPR133 couples to Gs protein. Bohnekamp J, et al. J Biol Chem, 2011 Dec 9. PMID 22025619, Free PMC Article
  2. A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133. Liebscher I, et al. Cell Rep, 2014 Dec 24. PMID 25533341, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor D1; adhesion G-protein coupled receptor D1
Names
G protein-coupled receptor 133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432114.1 → NP_001419043.1  adhesion G protein-coupled receptor D1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZF17

  2. NM_001432115.1 → NP_001419044.1  adhesion G protein-coupled receptor D1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    M0RAV7

  3. NM_001432116.1 → NP_001419045.1  adhesion G protein-coupled receptor D1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    33124981..33239778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598511.3 → XP_017454000.1  adhesion G-protein coupled receptor D1 isoform X2

    Related
    ENSRNOP00000066668.1, ENSRNOT00000073105.3
    Conserved Domains (3) summary
    pfam01825
    Location:507 → 547
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:563 → 799
    7tm_4; Olfactory receptor
    cl22861
    Location:141 → 241
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. XM_001070157.9 → XP_001070157.3  adhesion G-protein coupled receptor D1 isoform X1

    Related
    ENSRNOP00000055384.3, ENSRNOT00000058586.7
    Conserved Domains (3) summary
    pfam01825
    Location:539 → 579
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:595 → 831
    7tm_4; Olfactory receptor
    cl22861
    Location:173 → 273
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  3. XM_063271783.1 → XP_063127853.1  adhesion G-protein coupled receptor D1 isoform X4

  4. XM_039090099.2 → XP_038946027.1  adhesion G-protein coupled receptor D1 isoform X3

    Conserved Domains (4) summary
    smart00303
    Location:537 → 584
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:594 → 619
    7tm_GPCRs; TM helix 1 [structural motif]
    cl22861
    Location:175 → 273
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:592 → 720
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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