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Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 689248, updated on 27-Nov-2024

Summary

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Official Symbol
Ecscrprovided by RGD
Official Full Name
endothelial cell surface expressed chemotaxis and apoptosis regulatorprovided by RGD
Primary source
RGD:1594804
See related
EnsemblRapid:ENSRNOG00000039593 AllianceGenome:RGD:1594804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aria; Ecscr-ps1
Summary
Predicted to be involved in negative regulation of angiogenesis; positive regulation of endothelial cell apoptotic process; and positive regulation of proteasomal protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and plasma membrane. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 44.3), Heart (RPKM 18.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ecscr in Genome Data Viewer
Location:
18p11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27583791..27593184, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27309711..27319106, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28507167..28516567, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 24 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene small integral membrane protein 33 Neighboring gene stimulator of interferon response cGAMP interactor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy. Kitamura Y, et al. J Biol Chem, 2014 Jan 31. PMID 24338479, Free PMC Article
  2. Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Ikeda K, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416853, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies, reveal a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction.
    Title: Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endothelial cell surface expressed chemotaxis and apoptosis regulator; endothelial cell-specific chemotaxis regulator
Names
apoptosis regulator through modulating IAP expression
endothelial cell-specific chemotaxis regulator, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432559.1 → NP_001419488.1  endothelial cell surface expressed chemotaxis and apoptosis regulator isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6G5C4

  2. NM_001432560.1 → NP_001419489.1  endothelial cell surface expressed chemotaxis and apoptosis regulator isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6J2Z3, M0RCJ4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27583791..27593184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601093.3 → XP_017456582.1  endothelial cell-specific chemotaxis regulator isoform X5

    UniProtKB/TrEMBL
    A0A8I6A8X7

  2. XM_063277650.1 → XP_063133720.1  endothelial cell-specific chemotaxis regulator isoform X7

  3. XM_017601091.3 → XP_017456580.1  endothelial cell-specific chemotaxis regulator isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8X7
    Related
    ENSRNOP00000079454.2, ENSRNOT00000120258.2

  4. XM_017601092.3 → XP_017456581.1  endothelial cell-specific chemotaxis regulator isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8X7

  5. XM_008772057.4 → XP_008770279.1  endothelial cell-specific chemotaxis regulator isoform X4

    Related
    ENSRNOP00000067313.2, ENSRNOT00000072580.5
    Conserved Domains (1) summary
    pfam15820
    Location:125 → 222
    ECSCR; Endothelial cell-specific chemotaxis regulator

  6. XM_063277649.1 → XP_063133719.1  endothelial cell-specific chemotaxis regulator isoform X6

  7. XM_039097302.2 → XP_038953230.1  endothelial cell-specific chemotaxis regulator isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8X7
    Related
    ENSRNOP00000087965.2, ENSRNOT00000097911.2
    Conserved Domains (1) summary
    pfam15820
    Location:145 → 242
    ECSCR; Endothelial cell-specific chemotaxis regulator
Nucleotide Protein Strain
Heading Accession and Version

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