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Kat6b lysine acetyltransferase 6B [ Rattus norvegicus (Norway rat) ]

Gene ID: 688634, updated on 27-Nov-2024

Summary

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Official Symbol
Kat6bprovided by RGD
Official Full Name
lysine acetyltransferase 6Bprovided by RGD
Primary source
RGD:1566399
See related
EnsemblRapid:ENSRNOG00000012850 AllianceGenome:RGD:1566399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566399
Summary
Predicted to enable histone H3K14 acetyltransferase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 52.2), Brain (RPKM 49.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kat6b in Genome Data Viewer
Location:
15p16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2688535..2861443, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2638885..2811977, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2811933..2966833, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096899 Neighboring gene uncharacterized LOC108352871 Neighboring gene dual specificity phosphatase 29 Neighboring gene uncharacterized LOC134482074 Neighboring gene uncharacterized LOC102553460 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 2 Neighboring gene adenosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Can unknown predisposition in familial breast cancer be family-specific? Lynch H, et al. Breast J, 2013 Sep-Oct. PMID 23800003
  2. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore SD, et al. Cancer Res, 2004 Aug 15. PMID 15313893
  3. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Simpson MA, et al. Am J Hum Genet, 2012 Feb 10. PMID 22265017, Free PMC Article
  4. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. Champagne N, et al. J Biol Chem, 1999 Oct 1. PMID 10497217
  5. Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study. Kuo PH, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Jun 3. PMID 24444492

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AK9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BK12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K122 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K18 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K23 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K27 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K56 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K8 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT6B; lysine acetyltransferase 6B
Names
K(lysine) acetyltransferase 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433087.1 → NP_001420016.1  lysine acetyltransferase 6B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6GLZ3

  2. NM_001433088.1 → NP_001420017.1  lysine acetyltransferase 6B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    2688535..2861443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093710.2 → XP_038949638.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLZ3
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  2. XM_039093712.2 → XP_038949640.1  histone acetyltransferase KAT6B isoform X4

    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430 → 698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cl22851
    Location:213 → 271
    PHD_SF; PHD finger superfamily

  3. XM_039093707.2 → XP_038949635.1  histone acetyltransferase KAT6B isoform X1

    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  4. XM_039093713.2 → XP_038949641.1  histone acetyltransferase KAT6B isoform X5

    UniProtKB/TrEMBL
    A6KKS4
    Related
    ENSRNOP00000064386.4, ENSRNOT00000070893.4
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:367 → 635
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cl22851
    Location:213 → 271
    PHD_SF; PHD finger superfamily

  5. XM_039093711.2 → XP_038949639.1  histone acetyltransferase KAT6B isoform X2

    UniProtKB/TrEMBL
    A6KKS4, M0R4T9
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:539 → 807
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cl22851
    Location:213 → 271
    PHD_SF; PHD finger superfamily

  6. XM_063274843.1 → XP_063130913.1  histone acetyltransferase KAT6B isoform X6

  7. XM_063274842.1 → XP_063130912.1  histone acetyltransferase KAT6B isoform X5

  8. XM_063274841.1 → XP_063130911.1  histone acetyltransferase KAT6B isoform X4

  9. XM_063274839.1 → XP_063130909.1  histone acetyltransferase KAT6B isoform X2

    UniProtKB/TrEMBL
    M0R4T9

  10. XM_039093708.2 → XP_038949636.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLZ3
    Related
    ENSRNOP00000097238.1, ENSRNOT00000107992.2
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  11. XM_039093709.2 → XP_038949637.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLZ3
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  12. XM_063274840.1 → XP_063130910.1  histone acetyltransferase KAT6B isoform X3

  13. XM_039093716.2 → XP_038949644.1  histone acetyltransferase KAT6B isoform X7

    UniProtKB/TrEMBL
    A6KKS4
    Conserved Domains (1) summary
    PLN00104
    Location:45 → 313
    PLN00104; MYST -like histone acetyltransferase; Provisional
Nucleotide Protein Strain
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