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Fendrr Foxf1 adjacent non-coding developmental regulatory RNA [ Mus musculus (house mouse) ]

Gene ID: 68790, updated on 2-Nov-2024

Summary

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Official Symbol
Fendrrprovided by MGI
Official Full Name
Foxf1 adjacent non-coding developmental regulatory RNAprovided by MGI
Primary source
MGI:MGI:1916040
See related
Ensembl:ENSMUSG00000097336 AllianceGenome:MGI:1916040
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LL66; lincFoxf1; linc-Foxf1a; 1110050K14Rik
Summary
This gene encodes a spliced long non-coding RNA transcribed from a bidirectional promoter shared with Foxf1 on the opposite strand. The encoded transcript is essential for normal development of the heart and body wall. It is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It plays a role in cell fate determination in tissues derived from the lateral plate mesoderm. Knockout models reveal loss of this gene is lethal in mice. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
Expression
Biased expression in lung adult (RPKM 90.0), bladder adult (RPKM 43.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Fendrr in Genome Data Viewer
Location:
8 E1; 8 70.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121781621..121809849, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121054882..121083110, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33579 Neighboring gene predicted gene, 46071 Neighboring gene forkhead box F1 Neighboring gene methenyltetrahydrofolate synthetase domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element. Ali T, et al. Nucleic Acids Res, 2023 Jul 7. PMID 37207329, Free PMC Article
  2. LncRNA Fendrr: involvement in the protective role of nucleolin against H(2)O(2)-induced injury in cardiomyocytes. Chen C, et al. Redox Rep, 2023 Dec. PMID 36719027, Free PMC Article
  3. LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia. Wang LQ, et al. Mol Med, 2021 Apr 15. PMID 33858325, Free PMC Article
  4. Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis. Zhao SP, et al. Inflammation, 2021 Jun. PMID 33417179
  5. The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. Grote P, et al. RNA Biol, 2013 Oct. PMID 24036695, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production.
    Title: The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production.
  2. Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element.
    Title: Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element.
  3. LncRNA Fendrr: involvement in the protective role of nucleolin against H2O2-induced injury in cardiomyocytes.
    Title: LncRNA Fendrr: involvement in the protective role of nucleolin against H(2)O(2)-induced injury in cardiomyocytes.
  4. LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
    Title: LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
  5. LncRNA FENDRR promotes apoptosis of Leydig cells in late-onset hypogonadism by facilitating the degradation of Nrf2.
    Title: LncRNA FENDRR promotes apoptosis of Leydig cells in late-onset hypogonadism by facilitating the degradation of Nrf2.
  6. Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis.
    Title: Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis.
  7. LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia.
    Title: LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia.
  8. Long non-coding RNA FENDRR regulates IFNgamma-induced M1 phenotype in macrophages.
    Title: Long non-coding RNA FENDRR regulates IFNγ-induced M1 phenotype in macrophages.
  9. Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.
    Title: Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.
  10. FENDRR could promote the apoptosis of human brain microvascular endothelial cells via miR-126 regulating VEGFA in hypertensive intracerebral hemorrhage
    Title: LncRNA-FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within respiratory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_045471.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses an alternate 3' structure, resulting in a shorter transcript compared to variant 1.
    Source sequence(s)
    AC124170, AK087264, JQ973641
    Related
    ENSMUST00000181530.8

  2. NR_130109.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC124170, AK004221, JQ973641
    Related
    ENSMUST00000182264.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121781621..121809849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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