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Cox7a1 cytochrome c oxidase subunit 7A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687508, updated on 4-Jan-2025

Summary

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Symbol
Cox7a1provided by RGD
Full Name
cytochrome c oxidase subunit 7A1provided by RGD
Primary source
RGD:6496527
See related
EnsemblRapid:ENSRNOG00000076290 AllianceGenome:RGD:6496527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 166.1), Lung (RPKM 111.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox7a1 in Genome Data Viewer
Location:
1q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94549663..94572330)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85422162..85447530)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91070593..91096190, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 146 Neighboring gene prothymosin alpha, pseudogene 5 Neighboring gene ribosomal protein S24, pseudogene 2 Neighboring gene calpain, small subunit 1 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of respiratory chain complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 7A1
Names
cytochrome c oxidase subunit 7A1, mitochondrial
cytochrome c oxidase subunit 7A1, mitochondrial-like
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402200.1 → NP_001389129.1  cytochrome c oxidase subunit 7A1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J9U1, M0R5K3, M0RAY3
    Related
    ENSRNOP00000101597.1, ENSRNOT00000146299.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94549663..94572330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274198.1 → XP_063130268.1  cytochrome c oxidase subunit 7A1 isoform X1

  2. XM_063274204.1 → XP_063130274.1  cytochrome c oxidase subunit 7A1 isoform X3

    UniProtKB/TrEMBL
    M0R5K3, M0RAY3

  3. XM_063274200.1 → XP_063130270.1  cytochrome c oxidase subunit 7A1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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