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H2az2 H2A.Z variant histone 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685909, updated on 4-Jan-2025

Summary

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Official Symbol
H2az2provided by RGD
Official Full Name
H2A.Z variant histone 2provided by RGD
Primary source
RGD:1587865
See related
EnsemblRapid:ENSRNOG00000052275 AllianceGenome:RGD:1587865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
H2afv; H2A.Z-2
Summary
Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AZ2 (H2A.Z variant histone 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 1383.6), Thymus (RPKM 1160.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See H2az2 in Genome Data Viewer
Location:
14q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85507228..85526166, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81293304..81312209, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86687782..86706639, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A Neighboring gene small Cajal body-specific RNA 16 Neighboring gene protein MIX23-like Neighboring gene U1 small nuclear ribonucleoprotein C-like Neighboring gene purine rich element binding protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates. Dryhurst D, et al. BMC Biol, 2009 Dec 14. PMID 20003410, Free PMC Article
  2. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. Boyne MT 2nd, et al. J Proteome Res, 2006 Feb. PMID 16457589
  3. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Sigal A, et al. Nat Methods, 2006 Jul. PMID 16791210
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
H2A.Z variant histone 2
Names
H2A histone family, member V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106019.2 → NP_001099489.1  H2A.Z variant histone 2

    See identical proteins and their annotated locations for NP_001099489.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0A0MXW3, A6IKU4, D4AEC0
    Related
    ENSRNOP00000073832.1, ENSRNOT00000082893.3
    Conserved Domains (1) summary
    PLN00154
    Location:6 → 121
    PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    85507228..85526166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092453.2 → XP_038948381.1  H2A.Z variant histone 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AR37
    Related
    ENSRNOP00000083173.2, ENSRNOT00000103545.2
    Conserved Domains (1) summary
    PTZ00017
    Location:3 → 90
    PTZ00017; histone H2A; Provisional

  2. XM_017599381.3 → XP_017454870.1  H2A.Z variant histone 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ASE8
    Conserved Domains (1) summary
    PLN00154
    Location:2 → 95
    PLN00154; histone H2A; Provisional

  3. XM_006251388.5 → XP_006251450.1  H2A.Z variant histone 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AR37
    Conserved Domains (2) summary
    PTZ00017
    Location:18 → 105
    PTZ00017; histone H2A; Provisional
    cl23907
    Location:23 → 99
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  4. XM_006251387.5 → XP_006251449.1  H2A.Z variant histone 2 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MXW3, A0A8I6G659
    Related
    ENSRNOP00000099147.1, ENSRNOT00000164544.1
    Conserved Domains (2) summary
    PLN00154
    Location:8 → 136
    PLN00154; histone H2A; Provisional
    cd00074
    Location:23 → 137
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Nucleotide Protein Strain
Heading Accession and Version

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