Rrm1 ribonucleotide reductase catalytic subunit M1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rrm1provided by RGD
Official Full Name: ribonucleotide reductase catalytic subunit M1provided by RGD
Primary source: RGD:1592569
See related: EnsemblRapid:ENSRNOG00000045752 AllianceGenome:RGD:1592569
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; disordered domain specific binding activity; and identical protein binding activity. Involved in several processes, including cell proliferation in forebrain; male gonad development; and response to ionizing radiation. Located in cell projection; neuronal cell body; and nuclear envelope. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: NCBI's current annotation of the functional gene (chromosome 1) and a pseudogene (chromosome 14) are not consistent on all assemblies. The functional gene on the Celera assembly is currently annotated with the GeneID of the pseudogene on chromosome 14. [17 Jun 2014]
Expression: Biased expression in Thymus (RPKM 481.4), Spleen (RPKM 369.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (166235904..166260206)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156823960..156848262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167538387..167562688)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

overexpression of the ribonucleotide reductase (Rrm1 and Rrm2) complex would increase contractility of adult rat cardiomyocytes
Title: Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables purine nucleotide binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in forebrain	IEP Inferred from Expression Pattern more info	PubMed
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoside-diphosphate reductase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase large subunit

Names: ribonucleotide reductase M1

NP_001013254.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.