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Rnf180 ring finger protein 180 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685384, updated on 27-Nov-2024

Summary

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Official Symbol
Rnf180provided by RGD
Official Full Name
ring finger protein 180provided by RGD
Primary source
RGD:1595064
See related
EnsemblRapid:ENSRNOG00000043329 AllianceGenome:RGD:1595064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human RNF180 (ring finger protein 180). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 24.6), Testes (RPKM 7.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf180 in Genome Data Viewer
Location:
2q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (38064026..38244854, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (36330285..36511168, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (35718100..35892578, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 7 binding protein Neighboring gene trifunctional nucleotide phosphoesterase protein YfkN-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 5-hydroxytryptamine receptor 1A Neighboring gene ribosomal protein L17 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses. Kabayama M, et al. J Neurosci, 2013 Aug 7. PMID 23926250, Free PMC Article
  2. Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Ogawa M, et al. Genes Cells, 2008 Apr. PMID 18363970
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188174

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in norepinephrine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in serotonin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within serotonin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF180
NP_001128458.1
XP_038959062.2
XP_038959064.1
XP_063138620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134986.2 → NP_001128458.1  E3 ubiquitin-protein ligase RNF180

    See identical proteins and their annotated locations for NP_001128458.1

    Status: VALIDATED

    Source sequence(s)
    BC168657
    UniProtKB/TrEMBL
    B5DEG2, F1LRQ3
    Related
    ENSRNOP00000083351.2, ENSRNOT00000112277.2
    Conserved Domains (1) summary
    cd00162
    Location:432 → 477
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    38064026..38244854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282550.1 → XP_063138620.1  E3 ubiquitin-protein ligase RNF180 isoform X2

    Related
    ENSRNOP00000104655.1, ENSRNOT00000145284.1

  2. XM_039103136.2 → XP_038959064.1  E3 ubiquitin-protein ligase RNF180 isoform X2

    UniProtKB/TrEMBL
    F1LRQ3
    Conserved Domains (1) summary
    cd16554
    Location:431 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  3. XM_039103134.2 → XP_038959062.2  E3 ubiquitin-protein ligase RNF180 isoform X1

    UniProtKB/TrEMBL
    B5DEG2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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