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Ints1 integrator complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 68510, updated on 27-Nov-2024

Summary

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Official Symbol
Ints1provided by MGI
Official Full Name
integrator complex subunit 1provided by MGI
Primary source
MGI:MGI:1915760
See related
Ensembl:ENSMUSG00000029547 AllianceGenome:MGI:1915760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110015K06Rik
Summary
Acts upstream of or within several processes, including U2 snRNA 3'-end processing; inner cell mass cell proliferation; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in nucleus. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 35.7), adrenal adult (RPKM 20.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints1 in Genome Data Viewer
Location:
5 G2; 5 78.8 cM
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139737037..139761455, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139751282..139775702, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46926 Neighboring gene STARR-seq mESC enhancer starr_14696 Neighboring gene MICAL-like 2 Neighboring gene STARR-seq mESC enhancer starr_14697 Neighboring gene STARR-positive B cell enhancer ABC_E8087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene microRNA 7037 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene transmembrane protein 184a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. Nakayama M, et al. FASEB J, 2006 Aug. PMID 16807365
  2. Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. Hata T, et al. Biochim Biophys Acta, 2007 Jul. PMID 17544522
  3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1440

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in U2 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within U2 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blastocyst growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 1
Names
int1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026748.3 → NP_081024.4  integrator complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC167333
    Consensus CDS
    CCDS57399.1
    UniProtKB/Swiss-Prot
    Q0KK58, Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7
    UniProtKB/TrEMBL
    A0A0G2JDG8, K3W4P2
    Related
    ENSMUSP00000143789.3, ENSMUST00000200393.5
    Conserved Domains (1) summary
    pfam12432
    Location:352 → 432
    DUF3677; Protein of unknown function (DUF3677)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139737037..139761455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504729.5 → XP_006504792.1  integrator complex subunit 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JH17
    Related
    ENSMUSP00000072406.7, ENSMUST00000072607.9
    Conserved Domains (1) summary
    pfam12432
    Location:377 → 457
    DUF3677; Protein of unknown function (DUF3677)

  2. XM_006504728.5 → XP_006504791.1  integrator complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JH17
    Conserved Domains (1) summary
    pfam12432
    Location:377 → 457
    DUF3677; Protein of unknown function (DUF3677)

  3. XM_006504727.5 → XP_006504790.1  integrator complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JH17
    Conserved Domains (1) summary
    pfam12432
    Location:379 → 459
    DUF3677; Protein of unknown function (DUF3677)

RNA

  1. XR_003955703.2 RNA Sequence

  2. XR_003955704.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4S8.2 GenPept UniProtKB/Swiss-Prot:Q6P4S8

Gene LinkOut

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