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Plekha2 pleckstrin homology domain containing A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684785, updated on 9-Dec-2024

Summary

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Symbol
Plekha2provided by RGD
Full Name
pleckstrin homology domain containing A2provided by RGD
Primary source
RGD:1586710
See related
EnsemblRapid:ENSRNOG00000066109 AllianceGenome:RGD:1586710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including PDZ domain binding activity; fibronectin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 254.7), Lung (RPKM 188.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekha2 in Genome Data Viewer
Location:
16q12.4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73641338..73704068)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66938684..67000661)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71725649..71784432)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S28, pseudogene 1 Neighboring gene transforming, acidic coiled-coil containing protein 1 Neighboring gene uncharacterized LOC134482519 Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Kimber WA, et al. Biochem J, 2003 Dec 1. PMID 14516276, Free PMC Article
  2. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
  3. TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. Costantini JL, et al. Blood, 2009 Nov 19. PMID 19786618
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 2
Names
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427342.2 → NP_001414271.1  pleckstrin homology domain-containing family A member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZTX1, A6IW22
    Related
    ENSRNOP00000082311.2, ENSRNOT00000119625.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    73641338..73704068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095213.2 → XP_038951141.1  pleckstrin homology domain-containing family A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTX1, A6IW22
    Related
    ENSRNOP00000108210.1, ENSRNOT00000169533.1
    Conserved Domains (2) summary
    cd13270
    Location:1 → 119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  2. XM_039095214.2 → XP_038951142.1  pleckstrin homology domain-containing family A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTX1, A6IW22
    Conserved Domains (2) summary
    cd13270
    Location:1 → 119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
Nucleotide Protein Strain
Heading Accession and Version

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