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Pin4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684441, updated on 27-Nov-2024

Summary

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Official Symbol
Pin4provided by RGD
Official Full Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 4provided by RGD
Primary source
RGD:1590326
See related
EnsemblRapid:ENSRNOG00000050051 AllianceGenome:RGD:1590326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable bent DNA binding activity and double-stranded DNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in several cellular components, including mitochondrial matrix; nuclear lumen; and spindle. Predicted to be part of preribosome. Predicted to be active in nucleus. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 91.9), Heart (RPKM 84.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pin4 in Genome Data Viewer
Location:
Xq22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71272034..71278676)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67232066..67238709)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72004413..72011667)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome X open reading frame 49 like 1 Neighboring gene NHS-like 2 Neighboring gene retrotransposon Gag like 5 Neighboring gene uncharacterized LOC134484080 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 2 Neighboring gene ERCC excision repair 6 like, spindle assembly checkpoint helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. Fujiyama-Nakamura S, et al. Mol Cell Proteomics, 2009 Jul. PMID 19369196, Free PMC Article
  2. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Kessler D, et al. BMC Biol, 2007 Sep 17. PMID 17875217, Free PMC Article
  3. The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. Surmacz TA, et al. J Mol Biol, 2002 Aug 9. PMID 12144781
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables bent DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Names
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
NP_001388140.1
NP_001388141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401211.1 → NP_001388140.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6IQE1
    Related
    ENSRNOP00000067375.3, ENSRNOT00000073157.3

  2. NM_001401212.1 → NP_001388141.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    M0RCP9
    Conserved Domains (1) summary
    cl29122
    Location:41 → 142
    Rotamase_2; PPIC-type PPIASE domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    71272034..71278676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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