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Mrpl39 mitochondrial ribosomal protein L39 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684304, updated on 27-Nov-2024

Summary

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Official Symbol
Mrpl39provided by RGD
Official Full Name
mitochondrial ribosomal protein L39provided by RGD
Primary source
RGD:1591507
See related
EnsemblRapid:ENSRNOG00000047563 AllianceGenome:RGD:1591507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleotide binding activity. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 162.8), Thymus (RPKM 141.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl39 in Genome Data Viewer
Location:
11q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37266116..37281612, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23779655..23795146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24181605..24200022, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126A, pseudogene 3 Neighboring gene Mir155 host gene Neighboring gene microRNA 155 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene junctional adhesion molecule 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL39
Names
39S ribosomal protein L39, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398882.1 → NP_001385811.1  large ribosomal subunit protein mL39

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JL56, M0R6J0
    Related
    ENSRNOP00000065042.3, ENSRNOT00000074032.4
    Conserved Domains (1) summary
    PLN02908
    Location:27 → 270
    PLN02908; threonyl-tRNA synthetase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    37266116..37281612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088767.2 → XP_038944695.1  large ribosomal subunit protein mL39 isoform X1

    Conserved Domains (2) summary
    PLN02908
    Location:27 → 155
    PLN02908; threonyl-tRNA synthetase
    cd01616
    Location:63 → 125
    TGS; TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold

  2. XM_063270766.1 → XP_063126836.1  large ribosomal subunit protein mL39 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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