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Sik3 SIK family kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684112, updated on 27-Nov-2024

Summary

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Symbol
Sik3provided by RGD
Full Name
SIK family kinase 3provided by RGD
Primary source
RGD:1593938
See related
EnsemblRapid:ENSRNOG00000045931 AllianceGenome:RGD:1593938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of TOR signaling; and protein phosphorylation. Predicted to act upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Predicted to be active in cytoplasm. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 87.4), Kidney (RPKM 73.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sik3 in Genome Data Viewer
Location:
8q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55208969..55419138)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46312253..46522444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50310263..50520284)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 Neighboring gene ribosomal protein S26, pseudogene 6 Neighboring gene uncharacterized LOC120094333 Neighboring gene POU class 5 homeobox 1, pseudogene 1 Neighboring gene apolipoprotein A1 Neighboring gene apolipoprotein C3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling. Cai Y, et al. Arterioscler Thromb Vasc Biol, 2021 Sep. PMID 34196217, Free PMC Article
  2. The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. Csukasi F, et al. Sci Transl Med, 2018 Sep 19. PMID 30232230, Free PMC Article
  3. cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes. Berggreen C, et al. Cell Signal, 2012 Sep. PMID 22588126
  4. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Sasagawa S, et al. Development, 2012 Mar. PMID 22318228
  5. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. Lizcano JM, et al. EMBO J, 2004 Feb 25. PMID 14976552, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling.
    Title: Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endochondral ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase SIK3
NP_001258145.2
XP_017451401.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271216.2 → NP_001258145.2  serine/threonine-protein kinase SIK3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    M0RD40
    Related
    ENSRNOP00000067534.3, ENSRNOT00000073507.4
    Conserved Domains (2) summary
    cd14071
    Location:65 → 317
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    cl21463
    Location:346 → 390
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    55208969..55419138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595912.3 → XP_017451401.1  serine/threonine-protein kinase SIK3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0T3
    Related
    ENSRNOP00000084757.1, ENSRNOT00000098139.2
    Conserved Domains (3) summary
    smart00220
    Location:66 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14071
    Location:65 → 317
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    cl21463
    Location:346 → 390
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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