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Prss2l1 protease, serine, 2 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683849, updated on 9-Dec-2024

Summary

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Official Symbol
Prss2l1provided by RGD
Official Full Name
protease, serine, 2 like 1provided by RGD
Primary source
RGD:1597830
See related
EnsemblRapid:ENSRNOG00000050493 AllianceGenome:RGD:1597830
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 1096.6) and Liver (RPKM 397.5) See more
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Genomic context

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See Prss2l1 in Genome Data Viewer
Location:
4q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71310998..71314666)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70344338..70348069)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70755780..70759478)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protease, serine, 2, pseudogene 1 Neighboring gene anionic trypsin-2-like Neighboring gene serine protease 1 Neighboring gene T-cell receptor beta-1 chain C region-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anionic trypsin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    71310998..71314666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003749732.6 → XP_003749780.1  anionic trypsin-2

    See identical proteins and their annotated locations for XP_003749780.1

    UniProtKB/TrEMBL
    A6IF27, A6IF30, W4VSR6
    Related
    ENSRNOP00000043620.4, ENSRNOT00000043527.6
    Conserved Domains (2) summary
    smart00020
    Location:23 → 239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24 → 242
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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