Sri sorcin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sriprovided by RGD
Official Full Name: sorcinprovided by RGD
Primary source: RGD:1584485
See related: EnsemblRapid:ENSRNOG00000049780 AllianceGenome:RGD:1584485
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in heart development. Located in several cellular components, including T-tubule; Z disc; and dendritic spine neck. Biomarker of congestive heart failure. Orthologous to human SRI (sorcin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 342.8), Spleen (RPKM 305.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (26928338..26952980, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (25973493..25997879, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (23004657..23029233, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sorcin prevented 2-deoxyglucose-induced cytochrome c release.
Title: Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes.
Together with a dense distribution in the perimeter of the cell along a pool of RyRs, these properties make sorcin a viable candidate to modulate vascular tone in smooth muscle.
Title: Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BF404841 (e-PCR)
- UniSTS:247160

RH139017 (e-PCR)
- UniSTS:221103

RH129956 (e-PCR)
- UniSTS:213244

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of transcription factor	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in chromaffin granule membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine neck	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128190.1 → NP_001121662.1 sorcin

See identical proteins and their annotated locations for NP_001121662.1

Status: PROVISIONAL

Source sequence(s)

BC158845

UniProtKB/TrEMBL

A0A8I5ZTT7, B0BNJ1

Related

ENSRNOP00000081785.2, ENSRNOT00000094260.2

Conserved Domains (2) summary

cd00051
Location:75 → 130

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:112 → 161

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

26928338..26952980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236007.5 → XP_006236069.1 sorcin isoform X2

UniProtKB/TrEMBL

A0A8I5ZTT7, A0A8I5ZWU9

Related

ENSRNOP00000066499.3, ENSRNOT00000073790.4

Conserved Domains (2) summary

cd00051
Location:60 → 115

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:97 → 146

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_039108350.2 → XP_038964278.1 sorcin isoform X1

UniProtKB/TrEMBL

A0A8I5ZTT7

Related

ENSRNOP00000083569.2, ENSRNOT00000112226.2

Conserved Domains (1) summary

cd16187
Location:47 → 211

EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
XM_039108351.2 → XP_038964279.1 sorcin isoform X3

Conserved Domains (2) summary

cd15897
Location:74 → 102

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:74 → 108

EFh_PEF; The penta-EF hand (PEF) family
XM_063286687.1 → XP_063142757.1 sorcin isoform X4