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Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 683630, updated on 27-Nov-2024

Summary

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Official Symbol
Mat2bprovided by RGD
Official Full Name
methionine adenosyltransferase 2 non-catalytic beta subunitprovided by RGD
Primary source
RGD:1593534
See related
EnsemblRapid:ENSRNOG00000003177 AllianceGenome:RGD:1593534
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in nucleus. Predicted to be part of methionine adenosyltransferase complex. Orthologous to human MAT2B (methionine adenosyltransferase 2 non-catalytic beta subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 338.7), Brain (RPKM 338.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mat2b in Genome Data Viewer
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (25609202..25626694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (25106928..25122982, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (25832096..25848045, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene U4 spliceosomal RNA Neighboring gene hyaluronan-mediated motility receptor Neighboring gene NudC domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction. Li C, et al. Croat Med J, 2019 Oct 31. PMID 31686458, Free PMC Article
  2. Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups. He H, et al. Neuroreport, 2022 Mar 23. PMID 35287147
  3. Structure and function study of the complex that synthesizes S-adenosylmethionine. Murray B, et al. IUCrJ, 2014 Jul 1. PMID 25075345, Free PMC Article
  4. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). LeGros HL Jr, et al. J Biol Chem, 2000 Jan 28. PMID 10644686
  5. S-adenosylmethionine in liver health, injury, and cancer. Lu SC, et al. Physiol Rev, 2012 Oct. PMID 23073625, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
    Title: Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
  2. Investigated and confirmed protective effect of adipose-derived mesenchymal stem cells on miR-21-3p/methionine adenosyltransferase 2B (MAT2B) signal transduction in a rat ischemic brain injury model.
    Title: Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94725

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables methionine adenosyltransferase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine adenosyltransferase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables methionine adenosyltransferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosylmethionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in S-adenosylmethionine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methionine adenosyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of methionine adenosyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of methionine adenosyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine adenosyltransferase 2 subunit beta
Names
MAT II beta
methionine adenosyltransferase 2 beta subunit
methionine adenosyltransferase 2B
methionine adenosyltransferase II, beta
NP_001037747.1
XP_006246188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044282.1 → NP_001037747.1  methionine adenosyltransferase 2 subunit beta

    See identical proteins and their annotated locations for NP_001037747.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085899
    UniProtKB/Swiss-Prot
    Q5U2R0
    UniProtKB/TrEMBL
    A0A8L2Q226, A6HDK5
    Related
    ENSRNOP00000004269.7, ENSRNOT00000004269.8
    Conserved Domains (1) summary
    cd05254
    Location:30 → 316
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    25609202..25626694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246126.5 → XP_006246188.1  methionine adenosyltransferase 2 subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006246188.1

    UniProtKB/TrEMBL
    A0A0G2JT30, A0A8I5ZYI5, A6HDK4
    Related
    ENSRNOP00000084010.1, ENSRNOT00000118093.2
    Conserved Domains (1) summary
    cd05254
    Location:19 → 305
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2R0.1 GenPept UniProtKB/Swiss-Prot:Q5U2R0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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