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Uqcc1 ubiquinol-cytochrome c reductase complex assembly factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683512, updated on 4-Jan-2025

Summary

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Official Symbol
Uqcc1provided by RGD
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 1provided by RGD
Primary source
RGD:1585681
See related
EnsemblRapid:ENSRNOG00000048309 AllianceGenome:RGD:1585681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Uqcc
Summary
Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in cytoplasmic vesicle and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human UQCC1 (ubiquinol-cytochrome c reductase complex assembly factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 337.6), Muscle (RPKM 167.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uqcc1 in Genome Data Viewer
Location:
3q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164813398..164905892, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144353276..144445810, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151384965..151474112, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene family with sequence similarity 83, member C Neighboring gene uncharacterized LOC134486190 Neighboring gene growth differentiation factor 5 Neighboring gene centrosomal protein 250 Neighboring gene similar to human chromosome 20 open reading frame 173

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain. Vetter K, et al. Mech Dev, 2001 Jan. PMID 11118897
  2. Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression. Tucker EJ, et al. PLoS Genet, 2013. PMID 24385928, Free PMC Article
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase complex assembly factor 1
Names
ubiquinol-cytochrome c reductase complex chaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109446.2 → NP_001102916.1  ubiquinol-cytochrome c reductase complex assembly factor 1

    See identical proteins and their annotated locations for NP_001102916.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107807
    UniProtKB/TrEMBL
    A0A8I6G7D8, M0RAB6, Q32Q54
    Related
    ENSRNOP00000066461.1, ENSRNOT00000072679.4
    Conserved Domains (1) summary
    pfam03981
    Location:136 → 275
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164813398..164905892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105862.1 → XP_038961790.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G7D8
    Conserved Domains (1) summary
    pfam03981
    Location:155 → 290
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  2. XM_039105861.2 → XP_038961789.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X2

    UniProtKB/TrEMBL
    A6KI69
    Conserved Domains (1) summary
    pfam03981
    Location:37 → 172
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  3. XM_039105859.2 → XP_038961787.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X1

    Conserved Domains (1) summary
    pfam03981
    Location:136 → 195
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone
Nucleotide Protein Strain
Heading Accession and Version

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