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Krt42 keratin 42 [ Mus musculus (house mouse) ]

Gene ID: 68239, updated on 27-Nov-2024

Summary

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Official Symbol
Krt42provided by MGI
Official Full Name
keratin 42provided by MGI
Primary source
MGI:MGI:1915489
See related
Ensembl:ENSMUSG00000053654 AllianceGenome:MGI:1915489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K42; K17n; Ka22; CK-42; ecat6; 2410039E07Rik
Summary
Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Krt42 in Genome Data Viewer
Location:
11 D; 11 63.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100153708..100160777, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100262882..100269951, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 16 Neighboring gene keratin 17 Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206 Neighboring gene STARR-seq mESC enhancer starr_30725 Neighboring gene STARR-positive B cell enhancer ABC_E1148 Neighboring gene STARR-positive B cell enhancer ABC_E3019 Neighboring gene eukaryotic translation initiation factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. Tong X, et al. J Invest Dermatol, 2004 Apr. PMID 15102087
  2. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Mitsui K, et al. Cell, 2003 May 30. PMID 12787504
  3. Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma. Zieman AG, et al. Hum Mol Genet, 2019 Jul 1. PMID 31220272, Free PMC Article
  4. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
  5. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type I cytoskeletal 42
Names
cytokeratin-42
keratin 17n
predicted ortholog of type I keratin KA22
type I keratin KA22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212483.3 → NP_997648.2  keratin, type I cytoskeletal 42

    See identical proteins and their annotated locations for NP_997648.2

    Status: VALIDATED

    Source sequence(s)
    AL590873
    Consensus CDS
    CCDS25416.1
    UniProtKB/Swiss-Prot
    A7MAW4, Q2M1G8, Q6IFX2, Q6SEK1
    Related
    ENSMUSP00000017270.7, ENSMUST00000017270.8
    Conserved Domains (2) summary
    pfam00038
    Location:93 → 404
    Filament; Intermediate filament protein
    pfam07195
    Location:236 → 358
    FliD_C; Flagellar hook-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100153708..100160777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IFX2.1 GenPept UniProtKB/Swiss-Prot:Q6IFX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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