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Slc25a18 solute carrier family 25 member 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681896, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a18provided by RGD
Official Full Name
solute carrier family 25 member 18provided by RGD
Primary source
RGD:1590470
See related
EnsemblRapid:ENSRNOG00000042731 AllianceGenome:RGD:1590470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and amino acid:proton symporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Located in mitochondrial inner membrane. Orthologous to human SLC25A18 (solute carrier family 25 member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 124.1), Testes (RPKM 16.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a18 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155672939..155693549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154000808..154021373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153330069..153350447)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350753 Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene Bcl2-like 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
  2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105602

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid:proton symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables amino acid:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-glutamate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial glutamate carrier 2
Names
GC-2
glutamate carrier 2, mitochondrial
glutamate/H(+) symporter 2
solute carrier family 25 (glutamate carrier), member 18
solute carrier family 25 (mitochondrial carrier), member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044280.2 → NP_001037745.2  mitochondrial glutamate carrier 2

    See identical proteins and their annotated locations for NP_001037745.2

    Status: VALIDATED

    Source sequence(s)
    BC094517, BG380364, CB726923
    UniProtKB/Swiss-Prot
    Q505J6
    UniProtKB/TrEMBL
    A0A8I5ZRK2, A6ILB0
    Related
    ENSRNOP00000015561.4, ENSRNOT00000015560.9
    Conserved Domains (1) summary
    pfam00153
    Location:9 → 102
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    155672939..155693549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108348.2 → XP_038964276.1  mitochondrial glutamate carrier 2 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:124 → 209
    Mito_carr; Mitochondrial carrier protein

  2. XM_063286684.1 → XP_063142754.1  mitochondrial glutamate carrier 2 isoform X1

    UniProtKB/Swiss-Prot
    Q505J6
    UniProtKB/TrEMBL
    A6ILB0

  3. XM_039108347.1 → XP_038964275.1  mitochondrial glutamate carrier 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZRK2
    Related
    ENSRNOP00000081133.1, ENSRNOT00000113398.2
    Conserved Domains (1) summary
    pfam00153
    Location:176 → 261
    Mito_carr; Mitochondrial carrier protein

  4. XM_063286685.1 → XP_063142755.1  mitochondrial glutamate carrier 2 isoform X3

  5. XM_063286686.1 → XP_063142756.1  mitochondrial glutamate carrier 2 isoform X4

RNA

  1. XR_010065706.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505J6.2 GenPept UniProtKB/Swiss-Prot:Q505J6

Gene LinkOut

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