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Lrmda leucine rich melanocyte differentiation associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 681383, updated on 4-Jan-2025

Summary

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Official Symbol
Lrmdaprovided by RGD
Official Full Name
leucine rich melanocyte differentiation associatedprovided by RGD
Primary source
RGD:1596707
See related
EnsemblRapid:ENSRNOG00000069198 AllianceGenome:RGD:1596707
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in melanocyte differentiation. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VII. Orthologous to human LRMDA (leucine rich melanocyte differentiation associated). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 36.0), Spleen (RPKM 25.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrmda in Genome Data Viewer
Location:
15p16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (1275139..2334153, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (1223098..2284764, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (1269869..2346246, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693799 Neighboring gene U6 spliceosomal RNA Neighboring gene potassium calcium-activated channel subfamily M alpha 1 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA threonine (anticodon AGU) 13 Neighboring gene transfer RNA proline (anticodon AGG) 44 Neighboring gene zinc finger protein 503

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism. Grønskov K, et al. Am J Hum Genet, 2013 Mar 7. PMID 23395477, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in melanocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich melanocyte differentiation-associated protein
Names
leucine-rich repeat-containing protein C10orf11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109441.1 → NP_001102911.1  leucine-rich melanocyte differentiation-associated protein

    See identical proteins and their annotated locations for NP_001102911.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474061
    UniProtKB/TrEMBL
    A0A8I6GL34, A6KKT9
    Related
    ENSRNOP00000094277.2, ENSRNOT00000117097.2
    Conserved Domains (4) summary
    cd00116
    Location:27 → 113
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:34 → 54
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:54 → 93
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:53 → 112
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    1275139..2334153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274633.1 → XP_063130703.1  leucine-rich melanocyte differentiation-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6GL34, A6KKT9

  2. XM_063274632.1 → XP_063130702.1  leucine-rich melanocyte differentiation-associated protein isoform X4

  3. XM_063274635.1 → XP_063130705.1  leucine-rich melanocyte differentiation-associated protein isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZZ54

  4. XM_063274629.1 → XP_063130699.1  leucine-rich melanocyte differentiation-associated protein isoform X1

  5. XM_063274630.1 → XP_063130700.1  leucine-rich melanocyte differentiation-associated protein isoform X2

  6. XM_063274636.1 → XP_063130706.1  leucine-rich melanocyte differentiation-associated protein isoform X8

  7. XM_063274634.1 → XP_063130704.1  leucine-rich melanocyte differentiation-associated protein isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZZ54

  8. XM_063274631.1 → XP_063130701.1  leucine-rich melanocyte differentiation-associated protein isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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