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Haus3 HAUS augmin-like complex, subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680477, updated on 4-Jan-2025

Summary

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Official Symbol
Haus3provided by RGD
Official Full Name
HAUS augmin-like complex, subunit 3provided by RGD
Primary source
RGD:1591723
See related
EnsemblRapid:ENSRNOG00000069005 AllianceGenome:RGD:1591723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Orthologous to human HAUS3 (HAUS augmin like complex subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 100.1), Spleen (RPKM 82.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Haus3 in Genome Data Viewer
Location:
14q21
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80805036..80977012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76580549..76599542)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81837772..81857458)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096643 Neighboring gene Max dimerization protein 4 Neighboring gene N-acetyltransferase 8-like Neighboring gene NELL2 interacting cell ontogeny regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Lawo S, et al. Curr Biol, 2009 May 26. PMID 19427217
  2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Uehara R, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19369198, Free PMC Article
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109412.2 → NP_001102882.1  HAUS augmin-like complex subunit 3

    See identical proteins and their annotated locations for NP_001102882.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    B1WC65, F7F7L8
    Related
    ENSRNOP00000020576.5, ENSRNOT00000020576.7
    Conserved Domains (1) summary
    pfam14932
    Location:29 → 281
    HAUS-augmin3; HAUS augmin-like complex subunit 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    80805036..80977012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273606.1 → XP_063129676.1  HAUS augmin-like complex subunit 3 isoform X5

  2. XM_063273602.1 → XP_063129672.1  HAUS augmin-like complex subunit 3 isoform X1

  3. XM_063273609.1 → XP_063129679.1  HAUS augmin-like complex subunit 3 isoform X6

    UniProtKB/TrEMBL
    F1M178

  4. XM_063273600.1 → XP_063129670.1  HAUS augmin-like complex subunit 3 isoform X1

  5. XM_063273610.1 → XP_063129680.1  HAUS augmin-like complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    F1M178
    Related
    ENSRNOP00000054876.3, ENSRNOT00000058068.7

  6. XM_063273607.1 → XP_063129677.1  HAUS augmin-like complex subunit 3 isoform X6

    UniProtKB/TrEMBL
    F1M178
    Related
    ENSRNOP00000098993.1, ENSRNOT00000133007.1

  7. XM_063273603.1 → XP_063129673.1  HAUS augmin-like complex subunit 3 isoform X2

    Related
    ENSRNOP00000034638.6, ENSRNOT00000029784.9

  8. XM_063273605.1 → XP_063129675.1  HAUS augmin-like complex subunit 3 isoform X4

  9. XM_063273604.1 → XP_063129674.1  HAUS augmin-like complex subunit 3 isoform X3

  10. XM_063273601.1 → XP_063129671.1  HAUS augmin-like complex subunit 3 isoform X1

  11. XM_063273614.1 → XP_063129684.1  HAUS augmin-like complex subunit 3 isoform X10

  12. XM_063273612.1 → XP_063129682.1  HAUS augmin-like complex subunit 3 isoform X8

  13. XM_063273613.1 → XP_063129683.1  HAUS augmin-like complex subunit 3 isoform X9

  14. XM_063273615.1 → XP_063129685.1  HAUS augmin-like complex subunit 3 isoform X11

    UniProtKB/TrEMBL
    B1WC65, F7F7L8

  15. XM_063273608.1 → XP_063129678.1  HAUS augmin-like complex subunit 3 isoform X6

    UniProtKB/TrEMBL
    F1M178

  16. XM_039092838.2 → XP_038948766.1  HAUS augmin-like complex subunit 3 isoform X12

RNA

  1. XR_010057411.1 RNA Sequence

  2. XR_010057415.1 RNA Sequence

  3. XR_010057412.1 RNA Sequence

  4. XR_010057410.1 RNA Sequence

  5. XR_010057414.1 RNA Sequence

  6. XR_010057413.1 RNA Sequence

  7. XR_010057409.1 RNA Sequence

  8. XR_010057416.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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