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Haus8l2 HAUS augmin-like complex, subunit 8 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680121, updated on 4-Jan-2025

Summary

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Official Symbol
Haus8l2provided by RGD
Official Full Name
HAUS augmin-like complex, subunit 8 like 2provided by RGD
Primary source
RGD:1595502
See related
EnsemblRapid:ENSRNOG00000062985 AllianceGenome:RGD:1595502
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; ATP-dependent protein folding chaperone; and phosphatidylserine binding activity. Predicted to be involved in several processes, including late endosomal microautophagy; positive regulation by host of viral genome replication; and positive regulation of mRNA splicing, via spliceosome. Predicted to be located in several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Predicted to be part of spliceosomal complex. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Haus8l2 in Genome Data Viewer
Location:
11p12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (19074905..19077014)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (5628432..5630535)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (13499168..13501271)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 5 Neighboring gene cell adhesion molecule 2 Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 7 Neighboring gene arginine and serine rich coiled-coil 1, pseudogene 2 Neighboring gene uncharacterized LOC120095556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in late endosomal microautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation by host of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor ribbon synapse IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock cognate 71 kDa protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    19074905..19077014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088763.2 → XP_038944691.1  heat shock cognate 71 kDa protein-like

    UniProtKB/TrEMBL
    D4A4S3
    Related
    ENSRNOP00000108906.1, ENSRNOT00000013159.7
    Conserved Domains (1) summary
    PTZ00009
    Location:1 → 613
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein Strain
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