Alkbh7 alkB homolog 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alkbh7provided by RGD
Official Full Name: alkB homolog 7provided by RGD
Primary source: RGD:1598126
See related: EnsemblRapid:ENSRNOG00000047089 AllianceGenome:RGD:1598126
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including fatty acid metabolic process; regulation of lipid storage; and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 167.5), Kidney (RPKM 102.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1925896..1928048)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1838886..1841044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10045375..10047507, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130001 (e-PCR)
- UniSTS:213289

RH129643 (e-PCR)
- UniSTS:212940

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Names: AlkB-like protein 7; alkB, alkylation repair homolog 7; alkylated DNA repair protein alkB homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109384.1 → NP_001102854.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

See identical proteins and their annotated locations for NP_001102854.1

Status: PROVISIONAL

Source sequence(s)

CH474092

UniProtKB/TrEMBL

A6KQT7, M0R7T2

Related

ENSRNOP00000065514.1, ENSRNOT00000072118.3

Conserved Domains (1) summary

cl21496
Location:33 → 200

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1925896..1928048

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084196.2 → XP_038940124.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A7M8, A6KQT6

Related

ENSRNOP00000087380.1, ENSRNOT00000097182.2

Conserved Domains (1) summary

cl21496
Location:73 → 139

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily