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Lpgat1 lysophosphatidylglycerol acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679692, updated on 27-Nov-2024

Summary

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Official Symbol
Lpgat1provided by RGD
Official Full Name
lysophosphatidylglycerol acyltransferase 1provided by RGD
Primary source
RGD:1585897
See related
EnsemblRapid:ENSRNOG00000004402 AllianceGenome:RGD:1585897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 2-acylglycerol O-acyltransferase activity; 2-acylglycerophosphocholine O-acyltransferase activity; and lysophosphatidylethanolamine acyltransferase activity. Predicted to be involved in glycerolipid metabolic process and positive regulation of fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 371.4), Brain (RPKM 204.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lpgat1 in Genome Data Viewer
Location:
13q27
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105825630..105896366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103294622..103365372)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110397353..110470874)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18, pseudogene 10 Neighboring gene ribosomal protein L37 like 2 Neighboring gene uncharacterized LOC102555670 Neighboring gene uncharacterized LOC120096356 Neighboring gene NIMA-related kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Soh J, et al. Nat Med, 2013 Jul. PMID 23749231, Free PMC Article
  2. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 2-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidylethanolamine acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipid acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA:lysophosphatidylglycerol acyltransferase 1
NP_001102846.1
XP_038947018.1
XP_038947019.1
XP_063128667.1
XP_063128668.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109376.2 → NP_001102846.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1

    See identical proteins and their annotated locations for NP_001102846.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JH01, F1LTX8
    Related
    ENSRNOP00000062474.4, ENSRNOT00000064492.3
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 329
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    105825630..105896366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091091.1 → XP_038947019.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6JH01, F1LTX8
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 329
    Acyltransf_C; Acyltransferase C-terminus

  2. XM_063272597.1 → XP_063128667.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6JH01

  3. XM_039091090.2 → XP_038947018.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6JH01, F1LTX8
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 329
    Acyltransf_C; Acyltransferase C-terminus

  4. XM_063272598.1 → XP_063128668.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6JH01
Nucleotide Protein Strain
Heading Accession and Version

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