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Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 67955, updated on 4-Jan-2025

Summary

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Official Symbol
Sugt1provided by MGI
Official Full Name
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1915205
See related
Ensembl:ENSMUSG00000022024 AllianceGenome:MGI:1915205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGT1; 2410174K12Rik
Summary
Enables lncRNA binding activity. Acts upstream of or within kinetochore assembly; skeletal muscle satellite cell proliferation; and spindle organization. Located in cytoplasm and kinetochore. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.7), placenta adult (RPKM 20.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Sugt1 in Genome Data Viewer
Location:
14 D3; 14 42.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79825100..79868237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79587660..79630797)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene claspin homolog pseudogene Neighboring gene E74 like ETS transcription factor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411 Neighboring gene STARR-positive B cell enhancer ABC_E9903 Neighboring gene STARR-seq mESC enhancer starr_37267 Neighboring gene STARR-positive B cell enhancer ABC_E2430 Neighboring gene chondromodulin Neighboring gene predicted gene, 41218

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis. Yan R, et al. Autoimmunity, 2023 Dec. PMID 37317573
  2. The oncogenic role of the cochaperone Sgt1. Ogi H, et al. Oncogenesis, 2015 May 18. PMID 25985210, Free PMC Article
  3. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. Sbroggiò M, et al. FEBS Lett, 2008 Jun 11. PMID 18474241
  4. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Li Y, et al. Nat Commun, 2020 Jun 1. PMID 32483152, Free PMC Article
  5. Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. Liu XS, et al. Mol Cell Biol, 2012 Oct. PMID 22869522, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis.
    Title: miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis.
  2. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
    Title: Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
  3. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
    Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in kinetochore assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle satellite cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein SGT1 homolog
Names
suppressor of G2 allele of SKP1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026474.6 → NP_080750.1  protein SGT1 homolog

    See identical proteins and their annotated locations for NP_080750.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AK082328, AK141416
    Consensus CDS
    CCDS36988.1
    UniProtKB/Swiss-Prot
    Q3UF88, Q9CRE7, Q9CX34, Q9D8M6
    Related
    ENSMUSP00000052942.9, ENSMUST00000054908.10
    Conserved Domains (6) summary
    cd06489
    Location:146 → 229
    p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
    smart00028
    Location:45 → 78
    TPR; Tetratricopeptide repeats
    PLN03088
    Location:21 → 336
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:44 → 74
    TPR; TPR repeat [structural motif]
    cl22853
    Location:38 → 107
    Motor_domain; Myosin and Kinesin motor domain
    pfam05002
    Location:256 → 336
    SGS; SGS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79825100..79868237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CX34.3 GenPept UniProtKB/Swiss-Prot:Q9CX34

Gene LinkOut

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