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Elovl1 ELOVL fatty acid elongase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679532, updated on 4-Jan-2025

Summary

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Official Symbol
Elovl1provided by RGD
Official Full Name
ELOVL fatty acid elongase 1provided by RGD
Primary source
RGD:1587151
See related
EnsemblRapid:ENSRNOG00000028448 AllianceGenome:RGD:1587151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fatty acid elongase activity. Predicted to be involved in ceramide biosynthetic process; establishment of skin barrier; and fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 432.1), Lung (RPKM 286.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elovl1 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137246781..137251351)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131961478..131965961)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137255868..137260486)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene hydroxypyruvate isomerase Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene mediator complex subunit 8 Neighboring gene uncharacterized LOC103692460 Neighboring gene cell division cycle 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Note on the cytological localization of alkaline phosphatase. LORCH J. Q J Microsc Sci, 1947 Jun. PMID 20253178
  2. The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy. Ofman R, et al. EMBO Mol Med, 2010 Mar. PMID 20166112, Free PMC Article
  3. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Leonard AE, et al. Biochem J, 2000 Sep 15. PMID 10970790, Free PMC Article
  4. Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Sassa T, et al. Mol Cell Biol, 2013 Jul. PMID 23689133, Free PMC Article
  5. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Ohno Y, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937905, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, monounsaturated fatty acid ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
very long chain fatty acid elongase 1
Names
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
elongation of very long chain fatty acids protein 1
NP_001037740.1
XP_017449105.1
XP_017449106.1
XP_017449107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044275.1 → NP_001037740.1  very long chain fatty acid elongase 1

    See identical proteins and their annotated locations for NP_001037740.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085795
    UniProtKB/TrEMBL
    A0A0G2K8N7, Q5U2Z8
    Conserved Domains (1) summary
    pfam01151
    Location:23 → 260
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    137246781..137251351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593616.3 → XP_017449105.1  very long chain fatty acid elongase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8N7, Q5U2Z8
    Related
    ENSRNOP00000033374.2, ENSRNOT00000037160.5
    Conserved Domains (1) summary
    pfam01151
    Location:23 → 260
    ELO; GNS1/SUR4 family

  2. XM_017593618.3 → XP_017449107.1  very long chain fatty acid elongase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8N7, Q5U2Z8
    Conserved Domains (1) summary
    pfam01151
    Location:23 → 260
    ELO; GNS1/SUR4 family

  3. XM_017593617.3 → XP_017449106.1  very long chain fatty acid elongase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8N7, Q5U2Z8
    Conserved Domains (1) summary
    pfam01151
    Location:23 → 260
    ELO; GNS1/SUR4 family
Nucleotide Protein Strain
Heading Accession and Version

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