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Zbtb7c zinc finger and BTB domain containing 7C [ Rattus norvegicus (Norway rat) ]

Gene ID: 679155, updated on 27-Nov-2024

Summary

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Official Symbol
Zbtb7cprovided by RGD
Official Full Name
zinc finger and BTB domain containing 7Cprovided by RGD
Primary source
RGD:1591841
See related
EnsemblRapid:ENSRNOG00000047924 AllianceGenome:RGD:1591841
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of fat cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB7C (zinc finger and BTB domain containing 7C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 44.1), Kidney (RPKM 17.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb7c in Genome Data Viewer
Location:
18q12.2-q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (71716586..72045831)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (69441616..69765744)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (72124955..72462293)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene cap binding complex dependent translation initiation factor Neighboring gene uncharacterized LOC102548225 Neighboring gene uncharacterized LOC120098205 Neighboring gene uncharacterized LOC134483052 Neighboring gene uncharacterized LOC102556385 Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene SMAD family member 2 Neighboring gene uncharacterized LOC102549578

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. Reuter S, et al. EMBO J, 1998 Jan 2. PMID 9427755, Free PMC Article
  2. Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. Jeon BN, et al. J Lipid Res, 2012 Apr. PMID 22331133, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187929

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 7C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127375.1 → NP_001120847.1  zinc finger and BTB domain-containing protein 7C

    See identical proteins and their annotated locations for NP_001120847.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166476
    UniProtKB/TrEMBL
    A0A8I5ZST7, B2GV04
    Related
    ENSRNOP00000065115.1, ENSRNOT00000072519.3
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    71716586..72045831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097091.2 → XP_038953019.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZST7, B2GV04
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

  2. XM_039097092.2 → XP_038953020.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZST7, B2GV04
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

  3. XM_063277570.1 → XP_063133640.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    B2GV04

  4. XM_063277571.1 → XP_063133641.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    B2GV04

  5. XM_063277572.1 → XP_063133642.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    B2GV04

  6. XM_039097094.2 → XP_038953022.1  zinc finger and BTB domain-containing protein 7C isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZST7, B2GV04
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
Nucleotide Protein Strain
Heading Accession and Version

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