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Tsfm Ts translation elongation factor, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 679068, updated on 27-Nov-2024

Summary

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Official Symbol
Tsfmprovided by RGD
Official Full Name
Ts translation elongation factor, mitochondrialprovided by RGD
Primary source
RGD:1593058
See related
EnsemblRapid:ENSRNOG00000048843 AllianceGenome:RGD:1593058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
2A3-2; EF-Ts; EF-TsMt
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to be located in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 131.4), Adrenal (RPKM 113.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tsfm in Genome Data Viewer
Location:
7q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64714330..64750106, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62828997..62864784, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70311948..70319389, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351472 Neighboring gene CTD small phosphatase 2 Neighboring gene advillin Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy. Emperador S, et al. Eur J Hum Genet, 2016 Jan. PMID 27677415, Free PMC Article
  2. Identification and cloning of a new gene (2A3-2), homologous to human translational elongation factor, upregulated in a proliferating rat smooth muscle cell line and in carotid hyperplasia. Zibara K, et al. Arterioscler Thromb Vasc Biol, 1999 Jul. PMID 10397682
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongation factor Ts, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276476.1 → NP_001263405.1  elongation factor Ts, mitochondrial precursor

    Status: PROVISIONAL

    Source sequence(s)
    FQ220263
    UniProtKB/Swiss-Prot
    Q9QYU2
    Related
    ENSRNOP00000086749.1, ENSRNOT00000099205.2
    Conserved Domains (3) summary
    PRK09377
    Location:47 → 317
    tsf; elongation factor Ts; Provisional
    cd14275
    Location:47 → 83
    UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
    pfam00889
    Location:115 → 316
    EF_TS; Elongation factor TS

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64714330..64750106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079876.2 → XP_038935804.1  elongation factor Ts, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A8I6GEC9
    Conserved Domains (1) summary
    PRK09377
    Location:36 → 306
    tsf; elongation factor Ts; Provisional

  2. XM_039079874.2 → XP_038935802.1  elongation factor Ts, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9QYU2
    Conserved Domains (1) summary
    PRK09377
    Location:47 → 317
    tsf; elongation factor Ts; Provisional

  3. XM_039079875.2 → XP_038935803.1  elongation factor Ts, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9QYU2
    Related
    ENSRNOP00000107892.1, ENSRNOT00000136728.1
    Conserved Domains (1) summary
    PRK09377
    Location:47 → 316
    tsf; elongation factor Ts; Provisional

  4. XM_039079877.2 → XP_038935805.1  elongation factor Ts, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    Q9QYU2
    Related
    ENSRNOP00000064332.4, ENSRNOT00000071543.4
    Conserved Domains (1) summary
    PRK09377
    Location:47 → 318
    tsf; elongation factor Ts; Provisional

RNA

  1. XR_005486720.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYU2.1 GenPept UniProtKB/Swiss-Prot:Q9QYU2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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