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Fbxl18 F-box and leucine-rich repeat protein 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 678726, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxl18provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 18provided by RGD
Primary source
RGD:1596958
See related
EnsemblRapid:ENSRNOG00000001117 AllianceGenome:RGD:1596958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL18 (F-box and leucine rich repeat protein 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 33.2), Muscle (RPKM 32.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl18 in Genome Data Viewer
Location:
12p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16781901..16812728)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11674538..11701317)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13728155..13751781)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095836 Neighboring gene actin, beta Neighboring gene uncharacterized LOC108352424 Neighboring gene trinucleotide repeat containing 18 Neighboring gene uncharacterized LOC120095837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398874.1 → NP_001385803.1  F-box/LRR-repeat protein 18

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    Related
    ENSRNOP00000001479.8, ENSRNOT00000001479.8
    Conserved Domains (2) summary
    sd00034
    Location:522 → 548
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:22 → 57
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    16781901..16812728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598486.3 → XP_017453975.1  F-box/LRR-repeat protein 18 isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVT7
    Conserved Domains (2) summary
    sd00034
    Location:522 → 548
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:22 → 57
    F-box-like

  2. XM_063271648.1 → XP_063127718.1  F-box/LRR-repeat protein 18 isoform X2

  3. XM_063271649.1 → XP_063127719.1  F-box/LRR-repeat protein 18 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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