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ttc8 tetratricopeptide repeat domain 8 [ Danio rerio (zebrafish) ]

Gene ID: 678551, updated on 9-Dec-2024

Summary

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Official Symbol
ttc8provided by ZNC
Official Full Name
tetratricopeptide repeat domain 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8846
See related
Ensembl:ENSDARG00000099481 AllianceGenome:ZFIN:ZDB-GENE-030131-8846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bbs8; fk26c02; wu:fk26c02; zgc:136718
Summary
Acts upstream of or within several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of pigment granule localization. Predicted to be part of BBSome. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ttc8 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003335638.2 (12..3620, complement)
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_008805388.1 (1..958, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335638.2 (12..3620, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805388.1 (1..958, complement)

NW_003335638.2Genomic Context describing neighboring genes

NW_008805388.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. May-Simera HL, et al. Dev Biol, 2010 Sep 15. PMID 20643117
  2. Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Blacque OE, et al. Cell Mol Life Sci, 2006 Sep. PMID 16909204, Free PMC Article
  3. The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy. Hudak LM, et al. Invest Ophthalmol Vis Sci, 2010 Jul. PMID 20207966, Free PMC Article
  4. Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Tobin JL, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18443298, Free PMC Article
  5. Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning. Tayeh MK, et al. Hum Mol Genet, 2008 Jul 1. PMID 18381349, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish
    Title: Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC136718

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within actin filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within left/right pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within melanosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within otolith development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pigment granule aggregation in cell center IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BBSome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BBSome IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040309.1 → NP_001035399.1  tetratricopeptide repeat protein 8

    See identical proteins and their annotated locations for NP_001035399.1

    Status: PROVISIONAL

    Source sequence(s)
    BC115238
    UniProtKB/TrEMBL
    Q1RLX7
    Related
    ENSDARP00000140172.2, ENSDART00000165981.2
    Conserved Domains (3) summary
    COG0457
    Location:216 → 499
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:352 → 380
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:353 → 381
    TPR_1; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003335638.2 Reference GRCz11 Primary Assembly

    Range
    12..3620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 Primary Assembly

Genomic

  1. NW_008805388.1 Reference GRCz11 Primary Assembly

    Range
    1..958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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