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Rnf115 ring finger protein 115 [ Mus musculus (house mouse) ]

Gene ID: 67845, updated on 27-Nov-2024

Summary

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Official Symbol
Rnf115provided by MGI
Official Full Name
ring finger protein 115provided by MGI
Primary source
MGI:MGI:1915095
See related
Ensembl:ENSMUSG00000028098 AllianceGenome:MGI:1915095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp364; 2610028E05Rik
Summary
Enables ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and protein K63-linked ubiquitination. Located in cytosol. Is expressed in central nervous system and genitourinary system. Orthologous to human RNF115 (ring finger protein 115). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 14.4), CNS E14 (RPKM 14.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf115 in Genome Data Viewer
Location:
3 F2.1; 3 41.96 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96634869..96698471)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96727597..96791155)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix hydrolase 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene predicted gene, 22581 Neighboring gene CD160 antigen Neighboring gene RIKEN cDNA 4930442L01 gene Neighboring gene PDZ domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response. Feng J, et al. Cell Death Dis, 2023 Dec 21. PMID 38129372, Free PMC Article
  2. The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection. Bilkei-Gorzo O, et al. EMBO J, 2022 Dec 1. PMID 36281581, Free PMC Article
  3. RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer. Li R, et al. Cell Death Dis, 2020 Sep 26. PMID 32980859, Free PMC Article
  4. Rabring7, a novel Rab7 target protein with a RING finger motif. Mizuno K, et al. Mol Biol Cell, 2003 Sep. PMID 12972561, Free PMC Article
  5. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Zhang ZD, et al. Nat Commun, 2020 Nov 2. PMID 33139700, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response.
    Title: RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response.
  2. The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection.
    Title: The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection.
  3. RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.
    Title: RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.
  4. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
    Title: RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
  5. Rabring7 plays crucial roles as a Rab7 target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis (rabring7)
    Title: Rabring7, a novel Rab7 target protein with a RING finger motif.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF115
Names
RING-type E3 ubiquitin transferase RNF115
Rab7-interacting RING finger protein
Rabring7
rabring 7
zinc finger protein 364
NP_080682.3
XP_006502010.2
XP_030108633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026406.3 → NP_080682.3  E3 ubiquitin-protein ligase RNF115

    See identical proteins and their annotated locations for NP_080682.3

    Status: VALIDATED

    Source sequence(s)
    AC112261, AC127297
    Consensus CDS
    CCDS17647.1
    UniProtKB/Swiss-Prot
    Q8R5A1, Q9D0C1, Q9D885
    UniProtKB/TrEMBL
    Q3TWA8
    Related
    ENSMUSP00000029740.10, ENSMUST00000029740.14
    Conserved Domains (2) summary
    pfam13639
    Location:228 → 270
    zf-RING_2; Ring finger domain
    pfam14369
    Location:19 → 49
    zinc_ribbon_9; zinc-ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96634869..96698471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501947.5 → XP_006502010.2  E3 ubiquitin-protein ligase RNF115 isoform X1

    UniProtKB/TrEMBL
    Q3TWA8
    Conserved Domains (1) summary
    cd16800
    Location:188 → 234
    RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins

  2. XM_030252773.1 → XP_030108633.1  E3 ubiquitin-protein ligase RNF115 isoform X2

    Conserved Domains (1) summary
    cd16800
    Location:146 → 192
    RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0C1.1 GenPept UniProtKB/Swiss-Prot:Q9D0C1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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