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Snap47 synaptosomal-associated protein, 47 [ Mus musculus (house mouse) ]

Gene ID: 67826, updated on 27-Nov-2024

Summary

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Official Symbol
Snap47provided by MGI
Official Full Name
synaptosomal-associated protein, 47provided by MGI
Primary source
MGI:MGI:1915076
See related
Ensembl:ENSMUSG00000009894 AllianceGenome:MGI:1915076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNAP-47; 1110031B06Rik
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within long-term synaptic potentiation. Located in dendrite; membrane; and neuronal cell body. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; liver; pancreas; and spleen. Orthologous to human SNAP47 (synaptosome associated protein 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 109.4), cortex adult (RPKM 96.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Snap47 in Genome Data Viewer
Location:
11 B1.3; 11 37.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59297967..59340868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59407141..59450041, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 9A Neighboring gene predicted gene, 51865 Neighboring gene STARR-seq mESC enhancer starr_29623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:59198075-59198323 Neighboring gene serine protease 38 Neighboring gene predicted gene 15755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:59263537-59263646 Neighboring gene STARR-seq mESC enhancer starr_29624 Neighboring gene jumonji domain containing 4 Neighboring gene zinc finger protein 867 Neighboring gene ariadne homolog 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47. Urbina FL, et al. Cell Rep, 2021 Feb 9. PMID 33567284, Free PMC Article
  2. Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. Holt M, et al. J Biol Chem, 2006 Jun 23. PMID 16621800
  3. Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs. Corradini I, et al. Cereb Cortex, 2014 Feb. PMID 23064108
  4. LTP requires a unique postsynaptic SNARE fusion machinery. Jurado S, et al. Neuron, 2013 Feb 6. PMID 23395379, Free PMC Article
  5. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47.
    Title: TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47.
  2. SNAP-47 is a novel Qbc-SNARE with ubiquitous expression
    Title: Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptosomal-associated protein 47
Names
synaptosomal-associated 47 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356452.1 → NP_001343381.1  synaptosomal-associated protein 47 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoforn (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI842642, AK049330, BY104758, CD363532
    Consensus CDS
    CCDS24767.1
    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  2. NM_001356454.1 → NP_001343383.1  synaptosomal-associated protein 47 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, leading to a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI842642, AK028053, BY104758
    UniProtKB/TrEMBL
    B2FDF6
    Conserved Domains (2) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain

  3. NM_144521.3 → NP_653104.1  synaptosomal-associated protein 47 isoform 1

    See identical proteins and their annotated locations for NP_653104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI842642, AK028053, BY104758
    Consensus CDS
    CCDS24767.1
    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Related
    ENSMUSP00000010038.4, ENSMUST00000010038.10
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59297967..59340868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534022.5 → XP_006534085.1  synaptosomal-associated protein 47 isoform X1

    See identical proteins and their annotated locations for XP_006534085.1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  2. XM_036156921.1 → XP_036012814.1  synaptosomal-associated protein 47 isoform X2

    UniProtKB/TrEMBL
    B2FDF6
    Conserved Domains (2) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain

  3. XM_036156920.1 → XP_036012813.1  synaptosomal-associated protein 47 isoform X2

    UniProtKB/TrEMBL
    B2FDF6
    Conserved Domains (2) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain

  4. XM_006534024.5 → XP_006534087.1  synaptosomal-associated protein 47 isoform X1

    See identical proteins and their annotated locations for XP_006534087.1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  5. XM_006534023.2 → XP_006534086.1  synaptosomal-associated protein 47 isoform X1

    See identical proteins and their annotated locations for XP_006534086.1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  6. XM_036156922.1 → XP_036012815.1  synaptosomal-associated protein 47 isoform X2

    UniProtKB/TrEMBL
    B2FDF6
    Conserved Domains (2) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain

  7. XM_030246254.2 → XP_030102114.1  synaptosomal-associated protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  8. XM_030246252.2 → XP_030102112.1  synaptosomal-associated protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  9. XM_030246251.2 → XP_030102111.1  synaptosomal-associated protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  10. XM_030246253.2 → XP_030102113.1  synaptosomal-associated protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif

  11. XM_036156919.1 → XP_036012812.1  synaptosomal-associated protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q3UNK4, Q8BK87, Q8R570
    Conserved Domains (3) summary
    cd15888
    Location:106 → 170
    SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
    cl17171
    Location:2 → 98
    PH-like; Pleckstrin homology-like domain
    cl22856
    Location:353 → 411
    SNARE; SNARE motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R570.1 GenPept UniProtKB/Swiss-Prot:Q8R570

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