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LOC677692 beta-glucuronidase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 677692, updated on 18-Sep-2024

Summary

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Gene symbol
LOC677692
Gene description
beta-glucuronidase
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
GUSB; GUSBB
Summary
The human homolog of this gene, GUSB, encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. In human, the enzyme forms a homotetramer that is localized to the lysosome. Mutations in the human gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome. Compared to human, the rhesus macaque genome has a segmental duplication of this locus and may have two functional GUSB genes (GUSBa and GUSBb). However the protein coding status of the rhesus GUSBa and GUSBb genes remains provisional since there are small gaps in the Mmul_051212 assembly at these two loci. ESTs from other macaque species indicate that some macaque species can produce full-length GUSB transcripts. [provided by RefSeq, Oct 2010]
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Genomic context

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See LOC677692 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (53890682..53912929)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (50206867..50228805, complement)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106997374 Neighboring gene vitamin K epoxide reductase complex subunit 1-like protein 1 Neighboring gene vitamin K epoxide reductase complex subunit 1-like protein 1 Neighboring gene glucuronidase, beta, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Tkatchenko AV, et al. Proc Natl Acad Sci U S A, 2006 Mar 21. PMID 16537371, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-glucuronidase
Names
glucuronidase, beta, b
XP_014988875.1
XP_028701558.1
XP_028701559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    53890682..53912929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028845725.1 → XP_028701558.1  beta-glucuronidase isoform X1

    UniProtKB/TrEMBL
    H9YYQ3
    Conserved Domains (1) summary
    cl30613
    Location:27 → 631
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

  2. XM_028845726.1 → XP_028701559.1  beta-glucuronidase isoform X2

    Conserved Domains (1) summary
    cl30613
    Location:6 → 441
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

  3. XM_015133389.2 → XP_014988875.1  beta-glucuronidase isoform X3

    Conserved Domains (1) summary
    pfam02836
    Location:110 → 412
    Glyco_hydro_2_C; Glycosyl hydrolases family 2, TIM barrel domain
Nucleotide Protein
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Gene LinkOut

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