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Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67763, updated on 27-Nov-2024

Summary

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Official Symbol
Prpsap1provided by MGI
Official Full Name
phosphoribosyl pyrophosphate synthetase-associated protein 1provided by MGI
Primary source
MGI:MGI:1915013
See related
Ensembl:ENSMUSG00000015869 AllianceGenome:MGI:1915013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAP39; 5730409F23Rik
Summary
Predicted to enable enzyme regulator activity; identical protein binding activity; and kinase binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 235.5), small intestine adult (RPKM 111.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Prpsap1 in Genome Data Viewer
Location:
11 E2; 11 81.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116361641..116385739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116470816..116494913, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2 Neighboring gene STARR-positive B cell enhancer ABC_E7101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116351868-116352051 Neighboring gene ribosomal protein L36, pseudogene 1 Neighboring gene sphingosine kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. De Cegli R, et al. Nucleic Acids Res, 2013 Jan. PMID 23180766, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribose phosphate diphosphokinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphoribosyl pyrophosphate synthase-associated protein 1
Names
39 kDa phosphoribosypyrophosphate synthase-associated protein
39 kDa phosphoribosypyrophosphate synthetase-associated protein
PRPP synthase-associated protein 1
PRPP synthetase-associated protein 1
NP_001391595.1
NP_001391596.1
NP_001391597.1
NP_001391598.1
NP_080640.1
XP_011247498.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404666.1 → NP_001391595.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645851

  2. NM_001404667.1 → NP_001391596.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645851

  3. NM_001404668.1 → NP_001391597.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645851

  4. NM_001404669.1 → NP_001391598.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645851
    UniProtKB/TrEMBL
    B1AT84
    Related
    ENSMUSP00000115982.3, ENSMUST00000152496.9

  5. NM_026364.2 → NP_080640.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_080640.1

    Status: VALIDATED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS48985.1
    UniProtKB/Swiss-Prot
    Q9D0M1
    UniProtKB/TrEMBL
    B1AT82
    Related
    ENSMUSP00000101999.2, ENSMUST00000106391.8
    Conserved Domains (2) summary
    pfam13793
    Location:38 → 155
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:196 → 379
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116361641..116385739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249196.3 → XP_011247498.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9D0M1
    Conserved Domains (2) summary
    pfam14572
    Location:165 → 348
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain
    pfam13793
    Location:20 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0M1.1 GenPept UniProtKB/Swiss-Prot:Q9D0M1

Gene LinkOut

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