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Fam114a2 family with sequence similarity 114, member A2 [ Mus musculus (house mouse) ]

Gene ID: 67726, updated on 27-Nov-2024

Summary

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Official Symbol
Fam114a2provided by MGI
Official Full Name
family with sequence similarity 114, member A2provided by MGI
Primary source
MGI:MGI:1917629
See related
Ensembl:ENSMUSG00000020523 AllianceGenome:MGI:1917629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810073G14Rik; 9030624B09Rik
Summary
Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human FAM114A2 (family with sequence similarity 114 member A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 12.4), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam114a2 in Genome Data Viewer
Location:
11 B1.3; 11 35.27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57373816..57409482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57482990..57518656, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 53706 Neighboring gene STARR-positive B cell enhancer ABC_E1825 Neighboring gene microfibrillar-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_29572 Neighboring gene predicted gene, 51895 Neighboring gene RIKEN cDNA 4933424L21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:57458544-57458653 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse. Khan A, et al. Reprod Biol, 2021 Sep. PMID 34315090
  2. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse.
    Title: The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM114A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168667.1 → NP_001162138.1  protein FAM114A2 isoform 2

    See identical proteins and their annotated locations for NP_001162138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK149763, AL672236, BY134675
    Consensus CDS
    CCDS24717.1
    UniProtKB/Swiss-Prot
    Q8VE88
    Related
    ENSMUSP00000020831.7, ENSMUST00000020831.13
    Conserved Domains (1) summary
    pfam05334
    Location:70 → 236
    DUF719; Protein of unknown function (DUF719)

  2. NM_001168668.1 → NP_001162139.1  protein FAM114A2 isoform 1

    See identical proteins and their annotated locations for NP_001162139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL672236
    Consensus CDS
    CCDS48801.1
    UniProtKB/Swiss-Prot
    Q3UE42, Q5QNR1, Q8VE88, Q9D310
    Related
    ENSMUSP00000104478.2, ENSMUST00000108850.2
    Conserved Domains (2) summary
    pfam05334
    Location:77 → 243
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:4 → 99
    DUF5427; Family of unknown function (DUF5427)

  3. NM_026342.3 → NP_080618.1  protein FAM114A2 isoform 2

    See identical proteins and their annotated locations for NP_080618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK018570, AL672236, BY134675
    Consensus CDS
    CCDS24717.1
    UniProtKB/Swiss-Prot
    Q8VE88
    Conserved Domains (1) summary
    pfam05334
    Location:70 → 236
    DUF719; Protein of unknown function (DUF719)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57373816..57409482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534016.3 → XP_006534079.1  protein FAM114A2 isoform X1

    See identical proteins and their annotated locations for XP_006534079.1

    UniProtKB/Swiss-Prot
    Q3UE42, Q5QNR1, Q8VE88, Q9D310
    Conserved Domains (2) summary
    pfam05334
    Location:77 → 243
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:4 → 99
    DUF5427; Family of unknown function (DUF5427)

  2. XM_011249195.4 → XP_011247497.1  protein FAM114A2 isoform X2

    See identical proteins and their annotated locations for XP_011247497.1

    UniProtKB/Swiss-Prot
    Q8VE88
    Conserved Domains (1) summary
    pfam05334
    Location:70 → 236
    DUF719; Protein of unknown function (DUF719)

  3. XM_011249194.4 → XP_011247496.1  protein FAM114A2 isoform X1

    See identical proteins and their annotated locations for XP_011247496.1

    UniProtKB/Swiss-Prot
    Q3UE42, Q5QNR1, Q8VE88, Q9D310
    Conserved Domains (2) summary
    pfam05334
    Location:77 → 243
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:4 → 99
    DUF5427; Family of unknown function (DUF5427)

  4. XM_036156918.1 → XP_036012811.1  protein FAM114A2 isoform X5

    Conserved Domains (2) summary
    pfam05334
    Location:78 → 244
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:10 → 100
    DUF5427; Family of unknown function (DUF5427)

  5. XM_006534013.4 → XP_006534076.1  protein FAM114A2 isoform X3

    Conserved Domains (2) summary
    pfam05334
    Location:85 → 251
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:12 → 107
    DUF5427; Family of unknown function (DUF5427)

  6. XM_030246250.2 → XP_030102110.1  protein FAM114A2 isoform X6

    Conserved Domains (1) summary
    pfam05334
    Location:77 → 243
    DUF719; Protein of unknown function (DUF719)

  7. XM_006534014.4 → XP_006534077.1  protein FAM114A2 isoform X4

    Conserved Domains (2) summary
    pfam05334
    Location:84 → 250
    DUF719; Protein of unknown function (DUF719)
    pfam10310
    Location:11 → 106
    DUF5427; Family of unknown function (DUF5427)

RNA

  1. XR_004937011.1 RNA Sequence

  2. XR_001780047.1 RNA Sequence

  3. XR_003949494.1 RNA Sequence

  4. XR_004937010.1 RNA Sequence

  5. XR_004937009.1 RNA Sequence

  6. XR_004937008.1 RNA Sequence

  7. XR_879731.4 RNA Sequence

  8. XR_879730.4 RNA Sequence

  9. XR_001780046.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE88.2 GenPept UniProtKB/Swiss-Prot:Q8VE88

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